Amino Alcohol

Catalog Product Name CAS Number Inquiry
BAT-000360 Boc-L-alaninol 79069-13-9 Inquiry
BAT-002640 L-Leucinol hydrochloride Inquiry
BAT-000377 Fmoc-L-phenylalaninol 129397-83-7 Inquiry
BAT-000628 Fmoc-D-Phenylalaninol 130406-30-3 Inquiry
BAT-000617 (R)-N-Boc-piperidine-2-methanol 134441-61-5 Inquiry
BAT-000618 (S)-N-Boc-piperidine-2-methanol 134441-93-3 Inquiry
BAT-000676 L-Norvalinol 22724-81-8 Inquiry
BAT-000369 D-Phenylalaninol 5267-64-1 Inquiry
BAT-000670 D-Norvalinol 80696-30-6 Inquiry
BAT-008233 Me-Ala-ol HCl 40916-61-8 Inquiry
BAT-000362 Boc-L-phenylglycinol 117049-14-6 Inquiry
BAT-000387 Z-L-alaninol 66674-16-6 Inquiry
BAT-000679 N-Boc-L-cyclohexylglycinol 107202-39-1 Inquiry
BAT-000365 Boc-S-benzyl-L-cysteinol 139428-96-9 Inquiry
BAT-000608 Boc-DL-Prolinol 170491-63-1 Inquiry
BAT-000674 L-Isoleucinol 24629-25-2 Inquiry
BAT-000383 Na-Boc-Ne-Z-L-lysinol 82689-20-1 Inquiry
BAT-000364 Boc-S-4-methylbenzyl-D-cysteinol Inquiry
BAT-000374 Fmoc-L-asparaginol 260450-76-8 Inquiry
BAT-000375 Fmoc-L-glutaminol 260450-77-9 Inquiry

Introduction

Amino alcohols are a group of compounds that have both amino (-NH2) and  hydroxyl (-OH) groups. Amino alcohols are important structural elements that are frequently found in pharmaceutical agents and biologically active natural products. Within SciFinder®, more than 350,000 reactions are currently listed with amino alcohols with secondary alcohols and primary amines function as reactants take place. This fact indicates the diverse potential of these compounds in the chemical industry. Chiral amino alcohols are commonly used as drug intermediates and chiral ligands due to their good coordination ability of N and O atoms. They are widely used in medicine, chemical industry, materials and asymmetric synthesis.

Application

Medince: Cyclic amino alcohols form a large group of biologically active natural products; for example, quinine that is used for malaria treatment. One important class of cyclic amino alcohols is the polyhydroxylated alkaloids, also known as aza-sugars, e.g. castanospermine that was found to be a potent inhibitor of α- and β-glucosidases.

Intermediates: β-Amino alcohols are used as intermediates in the synthesis of a wide range of biologically active natural and synthetic products as well as in unnatural amino acids. The amino alcohols are generally derivatized to improve their chelating ability or to increase their steric directing effect and also used in asymmetric synthesis.

Chiral ligands: The β-amino alcohols also play an important role as chiral ligands, most commonly derived from natural sources. Chiral 1,2-amino alcohols are common structural motifs found in a vast array of natural and biologically active molecules.

Catalysts: Due to good coordination ability of nitrogen and oxygen atoms, amino alcohols can form complexes with many elements to generate chiral catalysts with excellent performance.

References:

  1. Vishal Srivastava, Pravin K. Singh, Sudhanshu Kanaujiac, Praveen P. Singh. Photoredox catalysed synthesis of amino alcohol. New Journal of Chemistry, 2018, 42(1): 688-691.
  2. Torsten Sehl, Zaira Maugeri, Dörte Rother. Multi-step synthesis strategies towards 1,2-amino alcohols with special emphasis on phenylpropanolamines. Journal of Molecular Catalysis B: Enzymatic, 2015, 114: 65-71.
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