Amino Alcohol

Catalog Product Name CAS Number Inquiry
BAT-001233 1-Azido-3,6,9-trioxaundecane-11-ol 86770-67-4 Inquiry
BAT-000684 N-Carbobenzoxy-β-alaninol 34637-22-4 Inquiry
BAT-000662 4-Amino-1-butanol 13325-10-5 Inquiry
BAT-004736 (R)-3-Isopropylamino-1,2-propanediol 97988-45-9 Inquiry
BAT-002663 10-(Carbobenzoxyamino)-1-decanol 96409-12-0 Inquiry
BAT-002593 Boc-D-Methioninol 91177-57-0 Inquiry
BAT-002635 4-Piperidylmethanol hydrochloride 90748-01-9 Inquiry
BAT-004738 (S)-3-Isopropylamino-1,2-propanediol 90742-94-2 Inquiry
BAT-000671 2-(Tert-butoxy)ethan-1-amine 88615-68-3 Inquiry
BAT-002632 H-L-Tyr-ol HCl 87745-27-5 Inquiry
BAT-002606 D-Methioninol 87206-44-8 Inquiry
BAT-007620 Azido-PEG5-alcohol 86770-68-5 Inquiry
BAT-000655 3-(tert-Butoxy)propylamine hydrochloride 864658-14-0 Inquiry
BAT-002643 L-β-Homoalaninol hydrochloride 863304-89-6 Inquiry
BAT-000629 Fmoc-D-Tryptophanol 86123-11-7 Inquiry
BAT-000653 L-Tyr(Bzl)-ol 85803-44-7 Inquiry
BAT-000640 L-Cysteinol(Bzl) 85803-43-6 Inquiry
BAT-000668 D-Cyclohexylglycinol 85711-13-3 Inquiry
BAT-002669 N-Carbobenzoxy-L-tert-leucinol 848777-16-2 Inquiry
BAT-000673 L-Cyclohexylglycinol 845714-30-9 Inquiry

Introduction

Amino alcohols are a group of compounds that have both amino (-NH2) and  hydroxyl (-OH) groups. Amino alcohols are important structural elements that are frequently found in pharmaceutical agents and biologically active natural products. Within SciFinder®, more than 350,000 reactions are currently listed with amino alcohols with secondary alcohols and primary amines function as reactants take place. This fact indicates the diverse potential of these compounds in the chemical industry. Chiral amino alcohols are commonly used as drug intermediates and chiral ligands due to their good coordination ability of N and O atoms. They are widely used in medicine, chemical industry, materials and asymmetric synthesis.

Application

Medince: Cyclic amino alcohols form a large group of biologically active natural products; for example, quinine that is used for malaria treatment. One important class of cyclic amino alcohols is the polyhydroxylated alkaloids, also known as aza-sugars, e.g. castanospermine that was found to be a potent inhibitor of α- and β-glucosidases.

Intermediates: β-Amino alcohols are used as intermediates in the synthesis of a wide range of biologically active natural and synthetic products as well as in unnatural amino acids. The amino alcohols are generally derivatized to improve their chelating ability or to increase their steric directing effect and also used in asymmetric synthesis.

Chiral ligands: The β-amino alcohols also play an important role as chiral ligands, most commonly derived from natural sources. Chiral 1,2-amino alcohols are common structural motifs found in a vast array of natural and biologically active molecules.

Catalysts: Due to good coordination ability of nitrogen and oxygen atoms, amino alcohols can form complexes with many elements to generate chiral catalysts with excellent performance.

References:

  1. Vishal Srivastava, Pravin K. Singh, Sudhanshu Kanaujiac, Praveen P. Singh. Photoredox catalysed synthesis of amino alcohol. New Journal of Chemistry, 2018, 42(1): 688-691.
  2. Torsten Sehl, Zaira Maugeri, Dörte Rother. Multi-step synthesis strategies towards 1,2-amino alcohols with special emphasis on phenylpropanolamines. Journal of Molecular Catalysis B: Enzymatic, 2015, 114: 65-71.
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