Cell Penetrating Peptides

Catalog Product Name CAS Number Inquiry
BAT-010596 Polymyxin B nonapeptide 86408-36-8 Inquiry
BAT-006082 HIV-1 TAT Protein Peptide 191936-91-1 Inquiry
BAT-013305 Pep-1-Cysteamine 863608-35-9 Inquiry
BAT-013362 Mastoparan X 72093-22-2 Inquiry
BAT-013296 TAT-C (48-57) 627079-23-6 Inquiry
BAT-009325 Pep-1 uncapped 395069-86-0 Inquiry
BAT-009369 TAT 48-57 253141-50-3 Inquiry
BAT-009326 Peptide C105Y 247572-63-0 Inquiry
BAT-013360 Cys(NPys)-Antennapedia Homeobox (43-58) amide 220337-24-6 Inquiry
BAT-013346 NGR Peptide 1 1926163-30-5 Inquiry
BAT-010547 Antennapedia Peptide 188842-14-0 Inquiry
BAT-013336 KALA 187987-64-0 Inquiry
BAT-013332 Hel 13-5 177942-21-1 Inquiry
BAT-013294 TAT (47-57), FAM-labeled 1676104-81-6 Inquiry
BAT-010710 TAT-Gap19 1507930-54-2 Inquiry
BAT-013307 Cys(Npys)-(Arg)9 1417221-06-7 Inquiry
BAT-009244 HIV-1 Rev 34-50 141237-50-5 Inquiry
BAT-013285 TAT-GluR23Y 1404188-93-7 Inquiry
BAT-013361 TAT 14 1362661-34-4 Inquiry
BAT-013282 Biotin-TAT (47-57) 1231898-25-1 Inquiry

Background

Cell Penetrating Peptides (CPPs) are a family of short, highly hydrophobic peptides with the function of penetrating cell membranes. CPPs are positively charged with the structure of less than 30 amino acids. Currently, CPPs are mainly applied to deliver bioactive substances such as oligopeptides, proteins, nucleotides or analogs, opening up new pathways for drug transcellular transport and providing new perspectives for improvement of drug delivery.

Classification

According to the amino acid composition, CPPs are classified into cationic and amphiphilic. Cationic CPPs are mainly rich in arginine and lysine, as representatives of nuclear transcription activator Tat protein derived peptide (YGRKKRRQRRR), Small molecule oligoarginine [(R) n] and small-molecule oligo-lysine [(K) n], etc. Except for oligo-lysine [(K) n], cationic CPPs contain at least one arginine residue. Amphiphilic CPPs are composed mainly of lysine, with other amino acid residues in hydrophilic or hydrophobic sequences, and exhibit an α-helical spatial conformation.

Applications in the delivery of bioactive substances

Although biomacromolecules are capable of modulating cell functions and exerting therapeutic effects, their large size as well as their negative electrical properties limit their therapeutic effects in vivo. Cross-linking of CCPs with small molecules such as paclitaxel, cyclosporine A and methotrexate empower their transcellular delivery and therefore, aggregated in the targeted tumor cells. One application for peptide and protein-based delivery is the cross-linking of TAT-penetrating peptides with transcription factor inhibitory peptides relevant to allergic diseases, which can reduce the inflammatory response of the body and therefore be used to treat allergic rhinitis and allergic asthma. Therapeutic nucleotides are highly hydrophilic and negatively charged, with minimal cellular uptake, and when CPPs and nucleotides bind non-covalently to form nanocomplexes the remodel nucleotides show improved cellular uptake.

Applications in bioimaging

The use of CCPs can enhance the penetration of reference agents and biosensors in organisms, such as enabling reference agents to cross the blood-brain barrier to detect fluorescence bio-signals in brain tissue, allowing radio-labeled antibodies to enter cells for radiation immunotherapy and radiation immunoassay, moreover, observing the process of virus infection of cells as well as propagation of virus particles between cells in real time.

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