Peptide inhibitors are a class of substances used to inhibit the biological function of peptides. Peptide inhibitors can be synthesized by acetylation, amidation, formylation, hydroxylation, lipid modification, methylation or phosphorylation of one or more amino acids in the target peptide sequence. Peptides inhibitors are widely used in food industry, cosmetics industry and medical research, and it could be expected that the importance of peptide inhibitors will increase with the manufacture of peptide inhibitors and the solution of performance problems.
Browning of vegetables and fruits will affect their appearance, smell and taste. The rate of enzymatic browning is determined by the concentration of activated tyrosinase and phenolic compounds in the tissue, available oxygen, pH value and temperature. Traditional browning inhibitors include ascorbic acid, citric acid and nitrite. Although the inhibition effect is excellent, it has serious side effects. The use of natural and harmless peptide inhibitors can achieve excellent inhibition of browning reaction without serious side effects.
Many components of natural peptide inhibitors can be used as skin whitening agents. However, some components have the problems of reduction of skin immunity, carcinogenic risk, easy decomposition and strict transportation conditions. Therefore, by modifying the polypeptide sequence, the effective and safe polypeptide inhibitor with shorter polypeptide length can have safety, improve the water solubility and permeability of peptide precursors, avoid the decomposition of protease in the process of peptide precursors, and then maintain the concentration of drugs.
Peptide inhibitors are widely used in research and medical practice. Peptides are mediators of biological functions. The unique intrinsic properties of peptides make peptides attractive therapeutic agents because of their relatively high biological activity, specificity and relatively low toxicity. However, peptides have disadvantages in vivo, such as relatively low stability, susceptibility to enzyme degradation, and relatively weak tumor penetration in cancer treatment. Peptide inhibitors synthesized by modifying natural peptides are feasible substitutes for other biological agents, and could be used in the fields of anti-tumor, anti-rheumatoid arthritis, anti-virus and so on.