Need Assistance?

  • US & Canada:
    +
  • UK: +
Peptide Linkers

Boc-Val-Cit-OH

CAS 870487-08-4
Catalog BAT-000855
Molecular Weight 374.43
Molecular Formula C16H30N4O6
Boc-Val-Cit-OH

Nα-Fmoc-Nε-bis(Boc-aminooxy)acetamido-L-Lysine

CAS 1008512-23-9
Catalog BAT-002551
Molecular Weight 641.70
Molecular Formula C33H43N3O10
Nα-Fmoc-Nε-bis(Boc-aminooxy)acetamido-L-Lysine

Fmoc-L-Lys(Boc-AEEA)-OH

CAS 1662688-16-5
Catalog BAT-002552
Molecular Weight 613.70
Molecular Formula C32H43N3O9
Fmoc-L-Lys(Boc-AEEA)-OH

2-[2-(2-Aminoethoxy)ethoxy]acetic Acid

CAS 134978-97-5
Catalog BAT-006212
Molecular Weight 163.17
Molecular Formula C6H13NO4
2-[2-(2-Aminoethoxy)ethoxy]acetic Acid

Fmoc-Val-Cit-PAB

CAS 159858-22-7
Catalog BAT-008972
Molecular Weight 601.704
Molecular Formula C33H39N5O6
Fmoc-Val-Cit-PAB

SMCC

CAS 71875-81-5
Catalog BAT-008981
Molecular Weight 334.32
Molecular Formula C16H18N2O6
SMCC

Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt

CAS 185332-92-7
Catalog BAT-014637
Molecular Weight 382.28
Molecular Formula C12H11N2NaO9S
Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt

Azido-PEG3-FLAG

CAS 2243206-95-1
Catalog BAT-014759
Molecular Weight 1242.22
Molecular Formula C50H75N13O24
Sequence Azido-PEG3-propionyl-DYKDDDDK
Azido-PEG3-FLAG

N-Biotinyl-N -(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine

CAS 305372-39-8
Catalog BAT-015392
Molecular Weight 525.62
Molecular Formula C23H35N5O7S
N-Biotinyl-N -(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine

Introduction of Peptide Linkers

As a class of protease-cleavable linkers, peptide linkers are an important component of antibody-drug conjugates (ADCs). Through chemical bonds, peptide linkers serve to connect active drugs to antibodies.

Background of Peptide Linkers

Through chemical links, ADCs could connect bioactive small molecule drugs to antibodies. As carriers, monoclonal antibodies are used to transport small molecule drugs to target cells. ADC drugs are composed of cytotoxic small molecule drugs, linkers and monoclonal antibodies. The main challenge of ADCs is determined by the linkers. Therefore, the overall success in developing effective, nontoxic and safe ADC drugs is to assemble an ideal chemical connector which links monoclonal antibodies and cytotoxic payload. Currently, there are two main types of ADCs linkers, cleavable linkers and non-cleavable linkers. As cleavable linkers, peptide linkers are characterized by blood flow stability and effectiveness in releasing intracellular payload.

Machine of Peptide Linkers

Peptide linkers are a kind of bridge between antibodies and toxic small molecules, which can be stable in vitro and circulatory system to avoid cytotoxicity caused by ADCs. When ADCs are internalized, peptide linkers can effectively disconnect and then release active small molecules. Small molecules diffuse to the action site and play an active role, so as to kill tumor cells.

Application of Peptide Linkers

ADC drugs containing peptide linkers could be used for anti-tumors. Peptide linkers use lysosomal proteases such as cathepsin B to recognize and cut off the connecting peptides to release drugs. For example, ADCs containing peptide linkers are stable in body fluid. After entering the target cells, they quickly digest and release auristatins (MMAEs) in the lysosome. MMAEs act on tubulin, thereby inhibiting tumor cell division and killing tumor cells.

Online Inquiry

Verification code
Inquiry Basket