Modified PNA Monomers

γ-functionalized
Catalog	Name	Structure	Inquiry
BAT-014375	Fmoc-γ-L-Glu(OtBu)-PNA-OH		Inquiry
BAT-014376	Boc-γ-L-Ser(Bn)PNA-OH		Inquiry
BAT-014377	Boc-γ-(R)-Diethylene Glycol(OH)-PNA-OH		Inquiry
BAT-014378	Boc-γ-(R)-Diethylene Glycol-PNA-OH		Inquiry
BAT-014379	Boc-γ-L-Ala-PNA-OH		Inquiry
BAT-014380	Boc-γ-L-Lys(Fmoc)-PNA-OH		Inquiry
BAT-014381	Boc-γ-L-Cys(Trt)-PNA-OH		Inquiry
BAT-014382	Boc-γ-L-Cys(PMB)-PNA-OH		Inquiry
α-functionalized
Catalog	Name	Structure	Inquiry
BAT-014383	Boc-α-Me(PMB)-PNA-OH		Inquiry
BAT-014384	Boc-α-Cys(PMB)-PNA-OH		Inquiry
BAT-014385	Fmoc-α-Lys(Boc)-PNA-OH		Inquiry
BAT-014386	Boc-α-dimethyl-PNA-OH		Inquiry
β-functionalized
Catalog	Name	Structure	Inquiry
BAT-014387	Fmoc-β-(S)-Me-PNA-OH		Inquiry
BAT-014388	Boc-β-(S)-Me-PNA-OH		Inquiry
BAT-014389	Boc-β-dimethyl-PNA-OH		Inquiry

Modified peptide nucleic acid (PNA) monomers refer to amino acid monomers used to modify PNA synthesis. The modified amino acid is the structural unit of PNA.

Introduction

PNA is a synthetic polymer similar to DNA or RNA. Similar to polypeptides, various purine and pyrimidine bases are connected to the backbone by methylene carbonyl groups.

Many modified especially orthogonal protected PNA monomers have been reported. The main differences of these PNA monomers include two aspects:

1. the type of protective group used when protecting the primary amine of the skeleton structure and the amino group outside the base ring
2. Modification method of amide skeleton structure.

PNA monomers are generally divided into three categories according to the types of orthogonal protection groups used, Boc orthogonal protection, Fmoc orthogonal protection and other orthogonal protection.

• Effect

Although PNA has many excellent physical and chemical properties, its monomer structure needs to be modified under certain conditions. The structural modification of PNA monomers can be divided into three parts, skeleton modification, base modification and skeleton and base simultaneous modification. For example, in order to improve the binding affinity between PNA and DNA, an L-alanine can be modified on the C₅ position of the monomer skeleton structure. Modification of PNA monomer structure can improve its performance in the following aspects:

1. Improve the binding affinity of PNA to DNA;
2. Improve the specificity of PNA for DNA recognition and reduce the probability of wrong pairing;
3. Improve the cell permeability of PNA.

• Synthesis

The basic route for the synthesis of PNA monomer is:

1. the synthesis of base acetic acid containing appropriate protective group;
2. the synthesis of peptide nucleic acid skeleton with amino, carboxyl and side chain containing protective group;
3. the two were condensed by using the condensation agent or mixed anhydride method;
4. the carboxyl protecting group is removed to obtain the modified PNA monomer.

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