2,4,5-Trifluoro-L-β-homophenylalanine hydrochloride
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2,4,5-Trifluoro-L-β-homophenylalanine hydrochloride

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2,4,5-Trifluoro-L-β-homophenylalanine hydrochloride is used as a reagent in the synthesis of valuable β-amylalkyl-β-amino acid enantiomers. It is also an impurity of Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of diabetes mellitus type 2.

Category
Fluorinated Amino Acids
Catalog number
BAT-006713
CAS number
1217809-78-3
Molecular Formula
C10H11ClF3NO2
Molecular Weight
269.65
2,4,5-Trifluoro-L-β-homophenylalanine hydrochloride
IUPAC Name
(3S)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid;hydrochloride
Synonyms
(S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid hydrochloride
Related CAS
1217854-08-4 (free base)
Appearance
Pale white solid
Purity
95%
Melting Point
216-222 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C10H10F3NO2.ClH/c11-7-4-9(13)8(12)2-5(7)1-6(14)3-10(15)16;/h2,4,6H,1,3,14H2,(H,15,16);1H/t6-;/m0./s1
InChI Key
FZHZEWNJQKHBTG-RGMNGODLSA-N
Canonical SMILES
C1=C(C(=CC(=C1F)F)F)CC(CC(=O)O)N.Cl
1. Trimethyl 2,2',2''-[1,3,5-triazine-2,4,6-tri-yltris-(aza-nedi-yl)]triacetate
Sérgio M F Vilela, Filipe A Almeida Paz, João P C Tomé, Verónica de Zea Bermudez, José A S Cavaleiro, João Rocha Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 20;66(Pt 12):o3243-4. doi: 10.1107/S1600536810047604.
The title compound, C(12)H(18)N(6)O(6), was synthesized via nucleophilic substitution by reacting 2,4,6-trichloro-1,3,5-triazine with glycine methyl ester hydro-chloride in reflux (dried toluene) under anhydrous atmosphere. Individual mol-ecules self-assemble via strong N-H⋯O hydrogen bonds into supra-molecular double tapes running parallel to the [010] crystallographic direction. The close packing of supra-molecular tapes is mediated by geometrical reasons in tandem with a number of weaker N-H⋯O and C-H⋯N hydrogen-bonding inter-actions.
2. Methyl 2-(4,6-dichloro-1,3,5-triazin-2-yl-amino)acetate
Sérgio M F Vilela, Filipe A Almeida Paz, João P C Tomé, Verónica de Zea Bermudez, José A S Cavaleiro, João Rocha Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 25;65(Pt 8):o1985-6. doi: 10.1107/S1600536809028670.
The title compound, C(6)H(6)Cl(2)N(4)O(2), was prepared by the nucleophilic substitution of 2,4,6-trichloro-1,3,5-triazine by glycine methyl ester hydro-chloride, and was isolated from the reaction by using flash chromatography. The crystal structure at 150 K reveals the presence two crystallographically independent mol-ecules in the asymmetric unit which differ in the orientation of the pendant methoxy-carbonyl group. Each mol-ecular unit is engaged in strong and highly directional N-H⋯N hydrogen-bonding inter-actions with a symmetry-related mol-ecule, forming supra-molecular dimers which act as the synthons in the crystal packing.
3. Intramolecular oxidative cyclization of N-(2,2,2-trifluoro-1-(phenylimino)ethyl)benzimidamide
Elham Kazemi, Ali Darehkordi Mol Divers. 2020 Nov;24(4):1301-1312. doi: 10.1007/s11030-019-09995-8. Epub 2019 Sep 25.
A fast and convenient method for synthesis of 1,3-diaryl-5-(trifluoromethyl)-1H-1,2,4-triazole compounds has been described via intramolecular oxidative cyclization of the N-(2,2,2-trifluoro-1-(arylimino)ethyl)benzimidamide intermediates by I2/KI in excellent yields without any purification. N-(2,2,2-Trifluoro-1-(arylimino)ethyl)benzimidamide intermediates which are used in this project have been synthesized from the reaction of N-aryl-2,2,2-trifluoroacetimidoyl chlorides and benzamide hydrochloride derivatives at room temperature for the first time.
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