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3-(3-Dimethylaminopropyl)-1-ethyl-carbodiimide hydrochloride

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

It is being used for the synthesis of amides. EDC HCl is also used as a coupling agent in the preparation of esters from carboxylic acids using dimethylaminopyridine as the catalyst. It is water-soluble carbodiimide, widely used for peptide coupling.

Category

Peptide Synthesis Reagents

Catalog number

BAT-004854

CAS number

25952-53-8

Molecular Formula

C8H17N3·HCl

Molecular Weight

191.70

3-(3-Dimethylaminopropyl)-1-ethyl-carbodiimide hydrochloride

Specification
Reference Reading

IUPAC Name

3-(((ethylimino)methylene)amino)-N,N-dimethylpropan-1-amine hydrochloride

Synonyms

EDC.HCL; 1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride; EDC hydrochloride; EDCI; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent; EDAP; 1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride; edac hcl; wsc hcl; N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride

Appearance

White to off-white crystals

Purity

98%

Density

0.877 g/mL at 20 °C

Melting Point

110-115 °C

Boiling Point

269.1 °C at 760 mmHg

Storage

Store at 2-8 °C

Solubility

Slightly soluble in Methanol, Water

InChI

InChI=1S/C8H17N3.ClH/c1-4-9-8-10-6-5-7-11(2)3;/h4-7H2,1-3H3;1H

InChI Key

FPQQSJJWHUJYPU-UHFFFAOYSA-N

Canonical SMILES

CCN=C=NCCCN(C)C.Cl

1.Chemical modification and serological properties of the 3-deoxy-alpha-D-manno-2-octulosonic acid-containing polysaccharide from Escherichia coli LP1092.

Jennings HJ, Roy R, Williams RE. Carbohydr Res. 1984 Jul 1;129:243-55.

The alpha-D configuration of the 3-deoxy-D-manno-2-octulosylonic acid residues in the E. coli LP1092 polysaccharide was definitively assigned by a comparison of its c.d. spectrum with those of methyl 3-deoxy-alpha- and -beta-D-manno-2-octulopyranosidonic acid. The c.d. spectrum of the polysaccharide showed a negative n----pi transition at 211 nm, associated with carboxyl groups, which correlated well with the negative band at 218 nm exhibited in the c.d. spectrum of the methyl alpha-D-glycoside. In contrast, the methyl beta-D-glycoside gave a positive band in the same region of its c.d. spectrum, at 221 nm. Treatment of the E. coli LP1092 polysaccharide with 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride yielded a modified polysaccharide containing O-acylisourea groups and intramolecular lactones, in addition to some unesterified carboxyl groups. Both forms of ester could be reduced to hydroxymethyl groups by sodium borohydride.