1.Halometasone monohydrate (0.05%) in occupational contact dermatitis.
Maiti R1, Sirka CS2, Shaju N3, Hota D1. Indian J Pharmacol. 2016 Mar-Apr;48(2):128-33. doi: 10.4103/0253-7613.178823.
OBJECTIVE: The impact of occupational contact dermatitis (OCD) is often underestimated because of underreporting, and its management is also inadequate, especially in developing countries. Topical corticosteroids have remained the first line treatment but till date, there is no study on efficacy and safety of halometasone in OCD, and there is a paucity of data on its comparative efficacy in allergic and irritant variety. This study aims to evaluate the efficacy and safety of halometasone in OCD and to compare its effect in allergic and irritant types of OCD.
2.FTIR, HATR and FT-Raman studies on the anhydrous and monohydrate species of maltose in aqueous solution.
Iramain MA1, Davies L2, Brandán SA3. Carbohydr Res. 2016 Apr 12;428:41-56. doi: 10.1016/j.carres.2016.04.013. [Epub ahead of print]
The structures of α- and β-maltose anhydrous and their corresponding monohydrated species were studied combining the FT-IR, FT-Raman and HATR spectra with DFT calculations. The four structures were optimized in gas and aqueous solution by using the hybrid B3LYP/6-31G* method. The self-consistent force field (SCRF) calculations together with the polarized continuum (PCM) model were used to study the systems in solution while the solvation energies were computed using the solvation model (SM). The calculated structural and vibrational properties could explain the anomerization of maltose in solution, as was reported in the literature while the natural bond orbital (NBO) analyses for those species support clearly the mutarotation equilibria between both forms in solution, evidencing the anhydrous forms the equilibrium: α (45%) ⇔ β (55%), similar to that experimentally reported at 20 °C. Bands of all the species observed in the vibrational spectra support the presence of the anomeric species of maltose in solution while the presence of dimeric species justify the intense IR bands observed in the higher wavenumbers region.
