1.PON-Sol: prediction of effects of amino acid substitutions on protein solubility.
Yang Y1, Niroula A2, Shen B3, Vihinen M2. Bioinformatics. 2016 Feb 19. pii: btw066. [Epub ahead of print]
MOTIVATION: Solubility is one of the fundamental protein properties. It is of great interest because of its relevance to protein expression. Reduced solubility and protein aggregation are also associated with many diseases.