1.Dissociative ionization of the 1-propanol dimer in a supersonic expansion under tunable synchrotron VUV radiation.
Tao Y1, Hu Y1, Xiao W1, Guan J2, Liu F3, Shan X3, Sheng L3. Phys Chem Chem Phys. 2016 May 3. [Epub ahead of print]
Photoionization and dissociation of the 1-propanol dimer and subsequent fragmentations have been investigated by synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry and theoretical calculations. Besides the protonated monomer cation (C3H7OH)·H+ (m/z = 61) and Cα-Cβ bond cleavage fragment CH2O·(C3H7OH)H+ (m/z = 91), the measured mass spectrum at an incident photon energy of 13 eV suggests a new dissociation channel resulting in the formation of the (C3H7OH)·H+·(C2H5OH) (m/z = 107) fragment. The appearance energies of the fragments (C3H7OH)·H+, CH2O·(C3H7OH)H+ and (C3H7OH)·H+·(C2H5OH) are measured at 10.05 ± 0.05 eV, 9.48 ± 0.05 eV, and 12.8 ± 0.1 eV, respectively, by scanning photoionization efficiency (PIE) spectra. The 1-propanol ion fragments as a function of VUV photon energy were interpreted with the aid of theoretical calculations. In addition to O-H and Cα-Cβ bond cleavage, a new dissociation channel related to Cβ-Cγ bond cleavage opens.
2.Effects of Omega-3 Fatty Acids Supplement on Antioxidant Enzymes Activity in Type 2 Diabetic Patients.
Toorang F1, Djazayery A2, Djalali M3. Iran J Public Health. 2016 Mar;45(3):340-5.
BACKGROUND: Diabetes is a major cause of death. Oxidative stress mainly caused by hyperglycemia is the primary reason of related complications. Omega-3 fatty acids are prescribed in diabetes but the effect on antioxidant defense is controversial. This study investigated effects of omega-3 supplementation on antioxidant enzymes activity in type 2 diabetic patients.
3.Lactic acid polarizes macrophages to a tumor-promoting state.
Colegio OR1. Oncoimmunology. 2015 Mar 19;5(3):e1014774. eCollection 2016.
Tumor-associated macrophages have been associated with a poor prognosis in most types of tumors. However, tumor-derived signals that activate macrophages have not been well defined. We review our recent finding that tumor-derived lactic acid is necessary and sufficient to polarize tumor-associated macrophages to a tumor-promoting state.
