9-Fluorenylmethoxycarbonylhydrazide hydrochloride
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9-Fluorenylmethoxycarbonylhydrazide hydrochloride

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Category
Others
Catalog number
BAT-002503
CAS number
872721-07-8
Molecular Formula
C15H15ClN2O2
Molecular Weight
290.75
Synonyms
Fmoc-NHNH2 HCl; Fmoc-hydrazide HCl; 9-Fluorenylmethyl carbazate hydrochloride
Related CAS
35661-51-9 (free base)
Storage
Store at 2-8 °C
1. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
2. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
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