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AAF-CMK trifluoroacetate salt

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AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome function, and reversibly inhibits Cln2 (TPPI).

Category

Peptide Inhibitors

Catalog number

BAT-015706

CAS number

184901-82-4

Molecular Formula

C18H23ClF3N3O5

Molecular Weight

453.84

Size	Price	Stock	Quantity
100 mg	$939	In stock

Specification

IUPAC Name

(2S)-2-amino-N-[(2S)-1-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-1-oxopropan-2-yl]propanamide;2,2,2-trifluoroacetic acid

Synonyms

N-Ala-Ala-Phe-CMK; Tripeptidyl Peptidase Inhibitor II; L-Alaninamide,L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-

Appearance

Crystalline Solid

Purity

≥95%

Sequence

H-Ala-Ala-Phe-CH2Cl

Storage

Store at -20°C

Solubility

Soluble in Water

InChI

InChI=1S/C16H22ClN3O3.C2HF3O2/c1-10(18)15(22)19-11(2)16(23)20-13(14(21)9-17)8-12-6-4-3-5-7-12;3-2(4,5)1(6)7/h3-7,10-11,13H,8-9,18H2,1-2H3,(H,19,22)(H,20,23);(H,6,7)/t10-,11-,13-;/m0./s1

InChI Key

ZFZXFWAYCYJFIZ-SQRKDXEHSA-N

Canonical SMILES

CC(C(=O)NC(=O)C(C)NC(CC1=CC=CC=C1)C(=O)CCl)N.C(=O)(C(F)(F)F)O