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Abz-Ser-Pro-3-nitro-Tyr-OH

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Abz-Ser-Pro-3-nitro-Tyr-OH, a selective internal quenching fluorescence (FRET) substrate for angiotensin-converting enzyme 2 (ACE2), has potential application in the high-throughput screening of ACE2 inhibitors (Km = 23 µM, kcat/Km = 3.5·10⁴ M^-1s^-1).

Category

Others

Catalog number

BAT-015356

CAS number

553644-01-2

Molecular Formula

C24H27N5O9

Molecular Weight

529.51

Specification

IUPAC Name

(2S)-2-[[(2S)-1-[(2S)-2-[(2-aminobenzoyl)amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxy-3-nitrophenyl)propanoic acid

Synonyms

H-2Abz-Ser-Pro-Tyr(3-NO2)-OH; (2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-L-tyrosine; L-Tyrosine, N-(2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-

Appearance

Yellow Lyophilized Powder

Purity

≥95%

Density

1.506±0.06 g/cm3 (Predicted)

Boiling Point

946.0±65.0°C (Predicted)

Sequence

Abz-Ser-Pro-Tyr(3-NO2)

Storage

Store at -20°C

Solubility

Soluble in Water

InChI

InChI=1S/C24H27N5O9/c25-15-5-2-1-4-14(15)21(32)27-17(12-30)23(34)28-9-3-6-18(28)22(33)26-16(24(35)36)10-13-7-8-20(31)19(11-13)29(37)38/h1-2,4-5,7-8,11,16-18,30-31H,3,6,9-10,12,25H2,(H,26,33)(H,27,32)(H,35,36)/t16-,17-,18-/m0/s1

InChI Key

RQLMBNGGUMATLG-BZSNNMDCSA-N

Canonical SMILES

C1CC(N(C1)C(=O)C(CO)NC(=O)C2=CC=CC=C2N)C(=O)NC(CC3=CC(=C(C=C3)O)[N+](=O)[O-])C(=O)O