2. Growth of bulk single crystal of N-acetyl DL-methionine and its spectral characterization
K Moovendaran, S Natarajan Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 25;135:317-20. doi: 10.1016/j.saa.2014.07.012. Epub 2014 Jul 15.
Bulk size single crystal of N-acetyl DL-methionine (C7H13NO3S) (1) was grown using a home-made crystal growth setup (MKN setup). The identity of the grown crystal was confirmed by single crystal X-ray diffraction. The modes of vibrations of the functional groups present were assigned using the infrared (IR) spectrum. UV-vis-NIR spectra showed that the crystals have excellent transparency in the visible and infrared regions. The thermal stability and decomposition of the sample was studied by using thermal analysis (TGA/DTA). Photoluminescence excitation studies showed that the emission occurred at 350 nm for the compound.
3. Effects of N-acetyl-DL-methionine on the liver, GSH synthesis and plasma ALAT level in male Bom:NMRI mice
L A Skoglund, K Ingebrigtsen, I Nafstad Gen Pharmacol. 1986;17(6):647-9. doi: 10.1016/0306-3623(86)90294-6.
A single high peroral dose of N-acetyl-DL-methionine (859.5 mg/kg) was administered to Bom:NMRI male mice using methylcellulose as a drug vehicle. The administration of a single high peroral dose of N-acetyl-DL-methionine (859.5 mg/kg) to Bom:NMRI male mice caused an inhibition of the hepatic glutathione decrease compared to a control group treated with methylcellulose only. N-acetyl-DL-methionine caused a reduction and time delay of the hepatic glutathione decrease found in the group treated with methylcellulose only. There was no observed cellular damage of the liver or kidneys assessed histologically or by plasma ALAT after dosing with a racemic mixture of N-acetyl-DL-methionine.
