Acetyl Hexapeptide-49 acetate
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Acetyl Hexapeptide-49 acetate

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Acetyl Hexapeptide-49 acetate is a photoprotectic cosmetic peptide that diminishes Proteinase-Activated Receptor 2 (PAR-2)-induced release of pro-inflammatory mediators, attenuating neurogenic inflammation and itch response in sensitive skin. It is recognized for its potential anti-aging and neurocosmetic properties. It works by inhibiting neurotransmitter release that causes muscle contractions, thereby reducing the appearance of wrinkles and fine lines. This peptide helps relax facial muscles, promoting a smoother and more youthful complexion. Additionally, it stimulates collagen synthesis, improves skin hydration, provides brightening effect, and has anti-inflammatory, freckle and acne-removing properties.

Category
Cosmetic Peptides
Catalog number
BAT-016153
Molecular Formula
C51H57N9O8.C2H4O2
Molecular Weight
948.12
Acetyl Hexapeptide-49 acetate
IUPAC Name
acetic acid;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoic acid
Synonyms
Acetyl Hexapeptide 49 acetate; Ac-Phe-Phe-Trp-Phe-His-Val-OH.C2H4O2; Ac-FFWFHV.C2H4O2; Acetyl-FFWFHV-OH.C2H4O2; N-Acetyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-phenylalanyl-L-histidyl-L-valine acetate
Related CAS
1969409-70-8 (free base)
Purity
≥95%
Sequence
Ac-Phe-Phe-Trp-Phe-His-Val.C2H4O2
Storage
Store at -20 °C
InChI
InChI=1S/C51H57N9O8.C2H4O2/c1-31(2)45(51(67)68)60-50(66)44(27-37-29-52-30-54-37)59-48(64)42(25-35-19-11-6-12-20-35)57-49(65)43(26-36-28-53-39-22-14-13-21-38(36)39)58-47(63)41(24-34-17-9-5-10-18-34)56-46(62)40(55-32(3)61)23-33-15-7-4-8-16-33;1-2(3)4/h4-22,28-31,40-45,53H,23-27H2,1-3H3,(H,52,54)(H,55,61)(H,56,62)(H,57,65)(H,58,63)(H,59,64)(H,60,66)(H,67,68);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-;/m0./s1
InChI Key
HGRDRAKEAWXMSV-RVNAAEMNSA-N
Canonical SMILES
CC(O)=O.CC(C)[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)CC3=CNC4=C3C=CC=C4)=O)CC5=CC=CC=C5)=O)CC6=CN=CN6)=O)C(O)=O
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