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Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It is a β-sheet breaker peptide that crosses the blood-brain barrier faster than most known proteins and peptides selectively absorbed by the brain, so it is assumed that the peptide is specifically transported to the brain.

Category

Functional Peptides

Catalog number

BAT-015329

CAS number

339990-02-2

Molecular Formula

C35H46N6O8

Molecular Weight

678.78

Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide

Specification

IUPAC Name

(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-acetamido-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-amino-4-oxobutanoic acid

Synonyms

iAβ5p; Ac-LPFFD-NH2; N-acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-isoasparagine; L-α-Asparagine, N-acetyl-L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-

Appearance

White Powder

Purity

≥95%

Density

1.268±0.06 g/cm3 (Predicted)

Boiling Point

1107.4±65.0°C (Predicted)

Sequence

Ac-Leu-Pro-Phe-Phe-Asp-NH2

Storage

Store at -20°C

Solubility

Soluble in Methanol

InChI

InChI=1S/C35H46N6O8/c1-21(2)17-28(37-22(3)42)35(49)41-16-10-15-29(41)34(48)40-27(19-24-13-8-5-9-14-24)33(47)39-26(18-23-11-6-4-7-12-23)32(46)38-25(31(36)45)20-30(43)44/h4-9,11-14,21,25-29H,10,15-20H2,1-3H3,(H2,36,45)(H,37,42)(H,38,46)(H,39,47)(H,40,48)(H,43,44)/t25-,26-,27-,28-,29-/m0/s1

InChI Key

DFIDZYQHBGZLHZ-ZIUUJSQJSA-N

Canonical SMILES

CC(C)CC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C