1. Total syntheses of amythiamicins A, B and C
K C Nicolaou, Dattatraya H Dethe, David Y-K Chen Chem Commun (Camb). 2008 Jun 21;(23):2632-4. doi: 10.1039/b805069b. Epub 2008 May 8.
Total syntheses of the thiopeptide antibiotics amythiamicins A, B and C are reported.
2. Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C
K Shimanaka, Y Takahashi, H Iinuma, H Naganawa, T Takeuchi J Antibiot (Tokyo). 1994 Oct;47(10):1153-9. doi: 10.7164/antibiotics.47.1153.
The structures of novel antimicrobial antibiotics, amythiamicins A, B and C, were elucidated by chemical degradations and NMR spectral analyses. The main frame from C-1 to C-41 of these antibiotics was the same as that of amythiamicin D. Amino acid autoanalyses of amythiamicins A, B and C showed that these have another one mole of serine and proline in comparison with amythiamicin D. Stereochemistries of both amino acids were determined to be L by chiral HPLC. These seryl-prolyl residues in amythiamicins A, B and C are attached at C-41 through an oxazoline ring, amide and ester bond, respectively.
3. Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum
B Clough, K Rangachari, M Strath, P R Preiser, R J Wilson Protist. 1999 Aug;150(2):189-95. doi: 10.1016/s1434-4610(99)70021-0.
Elongation factor Tu (EF-Tu) is encoded by the tuf gene of the plastid organelle of the malaria parasite Plasmodium falciparum. A range of structurally unrelated inhibitors of this GTP-dependent translation factor was shown to have antimalarial activity in blood cultures. The most active was the cyclic thiazolyl peptide amythiamicin A with an IC50 = 0.01 microM. Demonstrable complexes were formed in vitro between a recombinant version of P. falciparum EF-Tu(pl) and inhibitors that bind to different sites on EF-Tu; these included the antibiotics kirromycin, GE2270A and enacyloxin IIa.
