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(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676), a peptide substrate used to determine β-secretase activity, corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site.

Category

Functional Peptides

Catalog number

BAT-015111

CAS number

186142-28-9

Molecular Formula

C50H78N14O19

Molecular Weight

1179.24

(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)

Specification

IUPAC Name

(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid

Synonyms

(Asn670,Leu671)-APP770 (667-676); H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-OH; L-seryl-L-alpha-glutamyl-L-valyl-L-asparagyl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginine; (6S,9S,12S,15S,18S,21S,24S,27S,30S)-1-amino-24-(2-amino-2-oxoethyl)-30-((S)-2-amino-3-hydroxypropanamido)-9-benzyl-12-(2-carboxyethyl)-18-(carboxymethyl)-1-imino-21-isobutyl-27-isopropyl-15-methyl-8,11,14,17,20,23,26,29-octaoxo-2,7,10,13,16,19,22,25,28-nonaazadotriacontane-6,32-dicarboxylic acid

Appearance

White Solid

Purity

≥90%

Density

1.5±0.1 g/cm3

Sequence

SEVNLDAEFR

Storage

Store at -20°C

InChI

InChI=1S/C50H78N14O19/c1-23(2)18-31(60-47(80)33(20-35(52)66)63-48(81)39(24(3)4)64-43(76)29(14-16-37(69)70)58-41(74)27(51)22-65)45(78)62-34(21-38(71)72)44(77)56-25(5)40(73)57-28(13-15-36(67)68)42(75)61-32(19-26-10-7-6-8-11-26)46(79)59-30(49(82)83)12-9-17-55-50(53)54/h6-8,10-11,23-25,27-34,39,65H,9,12-22,51H2,1-5H3,(H2,52,66)(H,56,77)(H,57,73)(H,58,74)(H,59,79)(H,60,80)(H,61,75)(H,62,78)(H,63,81)(H,64,76)(H,67,68)(H,69,70)(H,71,72)(H,82,83)(H4,53,54,55)/t25-,27-,28-,29-,30-,31-,32-,33-,34-,39-/m0/s1

InChI Key

JONOLKHIDOKDGP-RDICLXJSSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CO)N