b-Chloro-L-alanine hydrochloride
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b-Chloro-L-alanine hydrochloride

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Category
L-Amino Acids
Catalog number
BAT-007904
CAS number
51887-89-9
Molecular Formula
C3H6NO2Cl·HCl
Molecular Weight
160.00
b-Chloro-L-alanine hydrochloride
IUPAC Name
(2R)-2-amino-3-chloropropanoic acid;hydrochloride
Synonyms
b-Chloro-L-Ala-OH HCl; (R)-2-Amino-3-chloropropionic acid hydrochloride; 3-Chloro-L-alanine Hydrochloride; beta-Chloro-L-alanine hydrochloride; L-Alanine, 3-chloro-, hydrochloride; 3-Chloro-l-alanine HCl; H-Ala(3-Cl)-OH HCl
Related CAS
2731-73-9 (free base)
Appearance
White solid
Purity
≥ 95% (HPLC)
Density
1.401 g/cm3
Melting Point
205 °C (dec.)
Boiling Point
243.6 °C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
InChI Key
IENJPSDBNBGIEL-DKWTVANSSA-N
Canonical SMILES
C(C(C(=O)O)N)Cl.Cl
1. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
2. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
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