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Bax inhibitor peptide V5

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Bax inhibitor peptide V5, a peptide inhibitor, as a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis

Category

Peptide Inhibitors

Catalog number

BAT-010188

CAS number

579492-81-2

Molecular Formula

C27H50N6O6S

Molecular Weight

586.8

Specification
Reference Reading

IUPAC Name

(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid

Synonyms

L-Valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine;

Appearance

Lyophilised solid

Purity

≥97% by HPLC

Density

1.185±0.06 g/cm3(Predicted)

Boiling Point

907.2±65.0°C(Predicted)

Sequence

H-Val-Pro-Met-Leu-Lys-OH

Storage

Store at -20°C

Solubility

Soluble in DMSO (≥29.35mg/mL), Water (≥91.4 mg/mL)

Application

A pro-apoptotic member of Bcl-2 family proteins

InChI

1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1

InChI Key

NHMUTADCTDDWPV-YFNVTMOMSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCSC)NC(=O)C1CCCN1C(=O)C(C(C)C)N

1.Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats.

Ma C1, Pan Y2, Yang Z3, Meng Z4, Sun R1, Wang T1, Fei Y1, Fan W1. Life Sci. 2016 Jan 1;144:113-20. doi: 10.1016/j.lfs.2015.11.019. Epub 2015 Dec 2.

AIMS: In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats.