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Beta-Sheet Breaker Peptide iAβ5

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Beta-Sheet Breaker Peptide iAβ5 inhibits amyloid formation in rat brain models.

Category

Peptide Inhibitors

Catalog number

BAT-016348

CAS number

182912-74-9

Molecular Formula

C33H43N5O8

Molecular Weight

637.72

Specification

IUPAC Name

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]butanedioic acid

Synonyms

L-Aspartic acid, L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-; L-Aspartic acid, N-[N-[N-(1-L-leucyl-L-prolyl)-L-phenylalanyl]-L-phenylalanyl]-; L-Leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartic acid; FibIII; Fibrillogenesis inhibitor III; IAβ5; H-Leu-Pro-Phe-Phe-Asp-OH; LPFFD

Related CAS

2763585-09-5 (acetate salt)

Purity

≥95%

Density

1.291±0.06 g/cm3

Boiling Point

980.0±65.0°C at 760 mmHg

Sequence

Leu-Pro-Phe-Phe-Asp

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C33H43N5O8/c1-20(2)16-23(34)32(44)38-15-9-14-27(38)31(43)36-25(18-22-12-7-4-8-13-22)29(41)35-24(17-21-10-5-3-6-11-21)30(42)37-26(33(45)46)19-28(39)40/h3-8,10-13,20,23-27H,9,14-19,34H2,1-2H3,(H,35,41)(H,36,43)(H,37,42)(H,39,40)(H,45,46)/t23-,24-,25-,26-,27-/m0/s1

InChI Key

RALAXQOLLAQGTI-IRGGMKSGSA-N

Canonical SMILES

CC(C)CC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(=O)O)C(=O)O)N