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Boc-3,4-difluoro-D-phenylalanine is used in the discovery of pyrrolopyrimidine inhibitors of Akt as antitumor agents.

BOC-Amino Acids
Catalog number
CAS number
Molecular Formula
Molecular Weight
(2R)-3-(3,4-difluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
Boc-D-Phe(3,4-DiF)-OH; Boc-3,4-difluoro-D-Phe-OH; (R)-Boc-2-amino-3-(3,4-difluorophenyl)propionic acid; BOC-d-3,4-Difluorophenylalanine; Boc-D-Phe(3,4-F2)-OH; boc-d-phe(3,4-dif)-oh; N-(tert-Butoxycarbonyl)-3,4-difluoro-D-phenylalanine; D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-3,4-difluoro-; J-300395; (r)-2-(tert-butoxycarbonylamino)-3-(3,4-difluorophenyl)propanoic acid; (2R)-3-(3,4-difluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
White to off-white powder
≥ 98% (HPLC)
1.270±0.06 g/cm3 (Predicted)
Melting Point
96-118 °C
Boiling Point
430.4±45.0 °C (Predicted)
Store at 2-8 °C
InChI Key
Canonical SMILES
1. Inhibitor mediated protein degradation
Marcus J C Long, Deviprasad R Gollapalli, Lizbeth Hedstrom Chem Biol. 2012 May 25;19(5):629-37. doi: 10.1016/j.chembiol.2012.04.008.
The discovery of drugs that cause the degradation of their target proteins has been largely serendipitous. Here we report that the tert-butyl carbamate-protected arginine (Boc(3)Arg) moiety provides a general strategy for the design of degradation-inducing inhibitors. The covalent inactivators ethacrynic acid and thiobenzofurazan cause the specific degradation of glutathione-S-transferase when linked to Boc(3)Arg. Similarly, the degradation of dihydrofolate reductase is induced when cells are treated with the noncovalent inhibitor trimethoprim linked to Boc(3)Arg. Degradation is rapid and robust, with 30%-80% of these abundant target proteins consumed within 1.3-5 hr. The proteasome is required for Boc(3)Arg-mediated degradation, but ATP is not necessary and the ubiquitin pathways do not appear to be involved. These results suggest that the Boc(3)Arg moiety may provide a general strategy to construct inhibitors that induce targeted protein degradation.
2. Synthesis of Simple 3,3-Diarylazetidines from N-Boc-3-arylazetidinols Using Friedel-Crafts Arylation Conditions
Madhurima Das, Amber Weissenfluh, Nam Ly, Mark L Trudell J Org Chem. 2020 Jun 19;85(12):8209-8213. doi: 10.1021/acs.joc.0c00454. Epub 2020 Jun 7.
A synthesis of 3,3-diarylazetidines from N-Boc-3-aryl-3-azetidinols using Friedel-Crafts arylation conditions with AlCl3 is described. A series of substituted diarylazetidines were readily prepared and isolated as the oxalate salts in high yield and high purity. The 3,3-diarylazetidine oxalates were then easily converted into N-alkyl and N-acyl analogues (RX, NaHCO3/DMF/100 °C) in high overall yields.
3. Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic acid
Eva Van Hende, Guido Verniest, Frederik Deroose, Jan-Willem Thuring, Gregor Macdonald, Norbert De Kimpe J Org Chem. 2009 Mar 6;74(5):2250-3. doi: 10.1021/jo802791r.
Synthetic strategies toward 3-fluoroazetidine-3-carboxylic acid, a new cyclic fluorinated beta-amino acid with high potential as building block in medicinal chemistry, were evaluated. The successful pathway includes the bromofluorination of N-(diphenylmethylidene)-2-(4-methoxyphenoxymethyl)-2-propenylamine, yielding 1-diphenylmethyl-3-hydroxymethyl-3-fluoroazetidine after reduction of the imino bond, ring closure, and removal of the 4-methoxybenzyl group. Changing the N-protecting group to a Boc-group allows further oxidation to 1-Boc-3-fluoroazetidine-3-carboxylic acid, a new fluorinated heterocyclic amino acid.
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