Boc-β-tert-butyl-L-alanine
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Boc-β-tert-butyl-L-alanine

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Category
BOC-Amino Acids
Catalog number
BAT-007191
CAS number
79777-82-5
Molecular Formula
C12H23NO4
Molecular Weight
245.32
Boc-β-tert-butyl-L-alanine
Size Price Stock Quantity
2.5 g $299 In stock
5 g $524 In stock
IUPAC Name
(2S)-4,4-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
Synonyms
Boc-β-tBu-L-Ala-OH; Boc-neopentylglycine; Boc β tBu L Ala OH
Appearance
White to off-white powder
Purity
≥ 99.5% (Chiral HPLC)
Density
1.048 g/cm3
Boiling Point
364.4°C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C12H23NO4/c1-11(2,3)7-8(9(14)15)13-10(16)17-12(4,5)6/h8H,7H2,1-6H3,(H,13,16)(H,14,15)/t8-/m0/s1
InChI Key
PUQVQDMFCAGQQB-QMMMGPOBSA-N
Canonical SMILES
CC(C)(C)CC(C(=O)O)NC(=O)OC(C)(C)C

Boc-β-tert-butyl-L-alanine, a chemically protective amino acid derivative crucial in peptide synthesis and pharmaceutical research, presents a myriad of applications. Here are the key applications expressed with high perplexity and burstiness:

Peptide Synthesis: Embracing Boc-β-tert-butyl-L-alanine as a pivotal building block in peptide synthesis, researchers harness its bulky Boc (tert-butoxycarbonyl) protecting group to shield the amino acid during chain elongation thwarting off undesired reactions. This meticulous process ensures the precise assembly of intricate peptides which serve as indispensable components in drug development and protein engineering endeavors.

Pharmaceutical Research: Within the realm of pharmaceutical research, Boc-β-tert-butyl-L-alanine emerges as a foundational element for crafting enzyme inhibitors and receptor agonists. Its distinctive structure facilitates the generation of bioactive compounds capable of modulating specific biological pathways. These compounds stand as linchpins in the pursuit of novel therapeutic agents targeting conditions like cancer infectious diseases and neurological disorders.

Structural Biology: Standing at the forefront of structural biology, Boc-β-tert-butyl-L-alanine assumes a pivotal role in enabling the synthesis of modified proteins. Researchers employ this derivative to delve into protein folding stability and interactions unraveling the nuances of protein function and fashioning proteins endowed with enhanced therapeutic attributes.

Bioconjugation: The versatility of Boc-β-tert-butyl-L-alanine shines in bioconjugation applications where it acts as a conduit for linking biomolecules with fluorescent dyes drugs or other functional groups. This intricate process lies at the crux of developing diagnostic tools targeted drug delivery systems and imaging agents that elevate the efficacy and specificity of biomedical interventions heralding a new era of precision medicine.

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