Boc-D-aspartic acid β-tert-butyl ester dicyclohexylammonium salt
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Boc-D-aspartic acid β-tert-butyl ester dicyclohexylammonium salt

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Category
BOC-Amino Acids
Catalog number
BAT-002710
CAS number
200334-95-8
Molecular Formula
C13H23NO6·C12H23N
Molecular Weight
470.60
Boc-D-aspartic acid β-tert-butyl ester dicyclohexylammonium salt
IUPAC Name
N-cyclohexylcyclohexanamine;(2R)-4-[(2-methylpropan-2-yl)oxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoic acid
Synonyms
Boc-D-Asp(OtBu)-OH DCHA; Dicyclohexylamine (R)-4-(tert-butoxy)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoate
Appearance
White powder
Purity
≥ 98% (HPLC)
Melting Point
138-144 °C
Storage
Store at 2-8°C
InChI
InChI=1S/C13H23NO6.C12H23N/c1-12(2,3)19-9(15)7-8(10(16)17)14-11(18)20-13(4,5)6;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h8H,7H2,1-6H3,(H,14,18)(H,16,17);11-13H,1-10H2/t8-;/m1./s1
InChI Key
OMYRDWOMNDCKEJ-DDWIOCJRSA-N
Canonical SMILES
CC(C)(C)OC(=O)CC(C(=O)O)NC(=O)OC(C)(C)C.C1CCC(CC1)NC2CCCCC2

Boc-D-aspartic acid β-tert-butyl ester dicyclohexylammonium salt is a versatile chemical compound crucial for peptide synthesis and medicinal chemistry. Here are four key applications highlighted with high perplexity and burstiness:

Peptide Synthesis: Serving as a fundamental building block in solid-phase peptide synthesis, Boc-D-aspartic acid β-tert-butyl ester dicyclohexylammonium salt plays a pivotal role in incorporating D-aspartic acid residues into peptides. This enables the creation of modified or conformationally constrained peptides with distinct structural and functional characteristics, essential in pharmaceuticals and advanced research endeavors.

Medicinal Chemistry: In the realm of medicinal chemistry, this compound contributes significantly to the design and synthesis of peptide-based drug candidates. Its protected groups allow for precise reactions, facilitating the construction of intricate molecules with exceptional purity. Researchers can craft peptide inhibitors, receptor agonists, or antagonists utilizing this compound, aiding in the exploration and development of novel therapeutic agents with promising biomedical applications.

Protein Engineering: Within the domain of protein engineering, Boc-D-aspartic acid β-tert-butyl ester dicyclohexylammonium salt is employed to introduce targeted amino acid modifications. This capability empowers scientists to engineer proteins with tailored properties, such as enhanced stability, reduced immunogenicity, or amplified binding affinity. Such modifications are pivotal for both foundational research and cutting-edge biotechnological innovations, pushing the boundaries of protein science and application.

Bioconjugation: Embracing bioconjugation techniques, this compound facilitates the chemical linkage of peptides or proteins to diverse molecules like drugs, fluorescent labels, or nanoparticles. Its utilization enables the controlled attachment of functional groups, enhancing the efficacy and specificity of bioconjugates. This process is vital for the advancement of sophisticated diagnostic and therapeutic tools in the realm of biomedical research, propelling breakthroughs in precision medicine and molecular imaging.

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