N,N'-Di-BOC-L-cystine

N,N’-Di-BOC-L-cystine, a derivative of the amino acid cystine, finds widespread use in diverse scientific realms. Here are four key applications of N,N’-Di-BOC-L-cystine:

Peptide Synthesis: A cornerstone in peptide and protein synthesis, N,N’-Di-BOC-L-cystine acts as a shielded variant of cystine, safeguarding thiol groups from undesired reactions during peptide chain construction. Following synthesis, acidic conditions strip away the protective BOC groups, unveiling the cystine-containing peptide.

Pharmaceutical Development: In the pharmaceutical arena, N,N’-Di-BOC-L-cystine plays a pivotal role in crafting drug molecules that target specific proteins or enzymes. Its shielded nature enables precise integration into drug candidates, thwarting premature disulfide bond formation and fostering the creation of potent and stable therapeutic agents.

Bioconjugation: Employed in bioconjugation strategies, N,N’-Di-BOC-L-cystine serves as a conduit for linking biomolecules through disulfide bonds. Selective deprotection of the shielded cystine facilitates the formation of disulfide crosslinks with other molecules, a boon for crafting conjugated antibodies, protein-drug hybrids, and diverse bioconjugates for research and therapeutic exploits.

Structural Biology: In the realm of structural biology, N,N’-Di-BOC-L-cystine emerges as a vital tool for introducing disulfide bonds into proteins and peptides, bolstering the stability of their intricate three-dimensional architectures. These bonds play a pivotal role in upholding the structural integrity and biological efficacy of proteins, aiding researchers in exploring protein folding, stability, and functionality to refine the design of robust protein-based therapeutics.