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Boc-Tyr(OtBu)-Aib-Gln(Trt)-Gly-Gly-OH is a protected pentapeptide used in peptide synthesis. The sequence comprises tyrosine (Tyr), α-aminoisobutyric acid (Aib), glutamine (Gln), and two glycine (Gly) residues. The Boc (tert-Butyloxycarbonyl) group protects the N-terminus of the tyrosine residue, while the OtBu (tert-butyl) group protects the hydroxyl group of tyrosine and the carboxyl group of glutamine. The Trt (Trityl) group shields the side chain of the glutamine residue, preventing it from reacting prematurely. The two glycine residues at the C-terminus are free, indicated by -OH, which facilitates further coupling or modifications. This peptide design ensures controlled reactivity and stability throughout synthesis, suitable for incorporation into larger peptide sequences.
