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Boc-Tyr(OtBu)-Aib-Glu(OtBu)-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the tyrosine (Tyr) residue, preventing it from reacting during the synthesis. The hydroxyl group of tyrosine and the side chain carboxyl group of glutamic acid (Glu) are protected by OtBu (tert-butyl) groups, which shield these functional groups from reactivity until deprotection is performed. Aib (α-aminoisobutyric acid), known for its ability to induce helical structures, is the middle residue in the sequence. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling or modifications. This peptide is utilized to incorporate tyrosine, Aib, and glutamic acid into peptides while maintaining precise control over the reactivity of the functional groups through specific protections.
