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Boc-Tyr(OtBu)-Aib-Gly-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the tyrosine (Tyr) residue, preventing it from reacting during synthesis. The hydroxyl group of tyrosine is protected by an OtBu (tert-butyl) group, which keeps it from reacting until deprotection is needed. Aib (α-aminoisobutyric acid), a non-natural amino acid known for inducing helical structures, follows tyrosine. Gly (Glycine), the final amino acid in the sequence, has a free carboxyl group at the C-terminus, indicated by -OH, allowing for further coupling or modifications. This compound is used to introduce tyrosine, Aib, and glycine into peptides, with selective protection of functional groups to ensure controlled and efficient peptide synthesis.
