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Boc-Tyr(OtBu)-Aib-OH is a protected dipeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the tyrosine (Tyr) residue, preventing it from reacting during peptide assembly. The hydroxyl group on the tyrosine side chain is also protected by a tBu (tert-butyl) group, ensuring that it remains unreactive until the desired deprotection step. Aib (α-aminoisobutyric acid) is the second amino acid in the sequence, a non-natural amino acid known for inducing helical structures in peptides. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is used to incorporate tyrosine and Aib into peptides, offering specific protective strategies for controlled synthesis and the introduction of conformational constraints.
