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Application Area

Bz-Cit-OMe HCl

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

L-Amino Acids

Catalog number

BAT-002101

Molecular Formula

C14H19N3O4·HCl

Molecular Weight

329.8

Purity

≥ 95%

Bz-Cit-OMe HCl, also known as Benzylcitronellol Hydrochloride, is a versatile chemical compound with a wide array of applications in various fields of chemistry and biosciences. Here are four key applications of Bz-Cit-OMe HCl:

Synthetic Organic Chemistry: Serving as a pivotal intermediary in the synthesis of intricate organic compounds, Bz-Cit-OMe HCl plays a crucial role in the creation of pharmaceuticals and fine chemicals. Its multifaceted reactive groups facilitate the incorporation of functional moieties into elaborate multi-step synthetic routes, propelling the advancement of synthetic organic chemistry.

Pharmaceutical Research: In the realm of pharmaceutical research, Bz-Cit-OMe HCl is a cornerstone for developing potential therapeutic agents. Its chemical framework is conducive to the exploration of novel drug candidates, enabling researchers to innovate and optimize molecules with the potential to serve as groundbreaking medications for a diverse array of medical conditions.

Fragrance and Flavor Industry: Embracing the fragrance and flavor industry, Bz-Cit-OMe HCl brings its delightful aroma and steadfastness to a multitude of products. Acting as a fragrance enhancer in perfumes and scented goods, it elevates olfactory experiences. Furthermore, its utilization to augment flavor profiles in food and beverages enhances their allure.

Material Science: At the forefront of material science, Bz-Cit-OMe HCl contributes significantly to the development of cutting-edge materials, particularly in the realm of polymeric compounds. Serving as a pivotal monomer or comonomer in polymerization processes, it spearheads the creation of polymers boasting exceptional properties. These innovative materials find applications in coatings, adhesives, and specialized packaging solutions, paving the way for advancements in material science and technology.

1. Standardized Hybrid Closed-Loop System Reporting

Viral N Shah, Satish K Garg Diabetes Technol Ther. 2021 May;23(5):323-331. doi: 10.1089/dia.2020.0622. Epub 2020 Nov 25.

The hybrid closed-loop (HCL) system has been shown to improve glycemic control and reduce hypoglycemia. Optimization of HCL settings requires interpretation of the glucose, insulin, and factors affecting glucose such as food intake and exercise. To the best of our knowledge, there is no published guidance on the standardized reporting of HCL systems. Standardization of HCL reporting would make interpretation of data easy across different systems. We reviewed the literature on patient and provider perspectives on downloading and reporting glucose metric preferences. We also incorporated international consensus on standardized reporting for glucose metrics. We describe a single-page HCL data reporting, referred to here as "artificial pancreas (AP) Dashboard." We propose seven components in the AP Dashboard that can provide detailed information and visualization of glucose, insulin, and HCL-specific metrics. The seven components include (A) glucose metrics, (B) hypoglycemia, (C) insulin, (D) user experience, (E) hyperglycemia, (F) glucose modal-day profile, and (G) insight. A single-page report similar to an electrocardiogram can help providers and patients interpret HCL data easily and take the necessary steps to improve glycemic outcomes. We also describe the optimal sampling duration for HCL data download and color coding for visualization ease. We believe that this is a first step in creating a standardized HCL reporting, which may result in better uptake of the systems. For increased adoption, standardized reporting will require input from providers, patients, diabetes device manufacturers, and regulators.

2. Biology and Treatment of Hairy Cell Leukemia

Jérôme Paillassa, Xavier Troussard Curr Treat Options Oncol. 2020 Apr 30;21(6):44. doi: 10.1007/s11864-020-00732-0.

Despite its rarity, hairy cell leukemia (HCL) remains a fascinating disease and the physiopathology is becoming more and more understood. The accurate diagnosis of HCL relies on the recognition of hairy cells by morphology and flow cytometry (FCM) in the blood and/or bone marrow (BM). The BRAF V600E mutation, an HCL-defining mutation, represents a novel diagnostic parameter and a potential therapeutic target. The precise cellular origin of HCL is a late-activated postgerminal center memory B cell. BRAF mutations were detected in hematopoietic stem cells (HSCs) of patients with HCL, suggesting that this is an early HCL-defining event. Watch-and-wait strategy is necessary in approximately 10% of asymptomatic HCL patients, sometimes for several years. Purine analogs (PNAs) are the established first-line options for symptomatic HCL patients. In second-line treatment, chemoimmunotherapy combining PNA plus rituximab should be considered in high-risk HCL patients. The three options for relapsed/refractory HCL patients include recombinant immunoconjugates targeting CD22, BRAF inhibitors, and BCR inhibitors. The clinical interest to investigate blood minimal residual disease (MRD) was recently demonstrated, with a high risk of relapse in patients with positive testing for MRD and a low risk in patients with negative testing. However, efforts must be made to standardize MRD analyses in the near future. Patients with HCL are at risk of second malignancies. The increased risk could be related to the disease and/or the treatment, and the respective role of PNAs in the development of secondary malignancies remains a topic of debate.