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CALP3 is a calcium-like peptide that contains the first eight residues of CALP2, which is a 12-residue peptide that interacts with EF hand motif 4 in human calmodulin to activate it in the absence of calcium. It acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons with IC50 of 37.25 µM. It also inhibits excitatory cytotoxicity with IC50 of 50.97 µM and apoptosis with IC50 of 33.41 µM. CALP3 was used to study as a new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis.
