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Cbz-Ile-Aib-Leu-OH is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the isoleucine (Ile) residue, preventing it from reacting during synthesis. Aib (α-aminoisobutyric acid), a non-natural amino acid known for inducing helical structures, follows isoleucine. Leu (Leucine), the final amino acid in the sequence, adds hydrophobic properties. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling or modifications. This compound is used to introduce isoleucine, Aib, and leucine into peptides while controlling the reactivity of their functional groups through selective protection.
