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Cbz-Thr(tBu)-Phe-Thr(tBu)-OH is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the threonine (Thr) residue, preventing it from reacting during synthesis. Both threonine residues have their side chain hydroxyl groups protected by tBu (tert-butyl) groups, which shield these groups from unwanted reactions until deprotection is desired. Phe (Phenylalanine), the central amino acid in the sequence, adds aromatic and hydrophobic properties to the peptide. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is used to incorporate threonine and phenylalanine into peptides while maintaining control over the functional groups' reactivity through selective protection.
