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It is a peptide extracted from the rabies virus glycoprotein (RVG). Since neurotropic viruses infect brain cells across the blood-brain barrier, the same strategy could be used to enter the central nervous system and deliver siRNA to the brain. To enable siRNA to bind, this chimeric peptide is synthesized by adding a non-Amer arginine residue to the carboxyl terminus of RVG. The RVG-9R peptide binds and transduces siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. Rvg-9r provides a safe, non-invasive method for delivering siRNA and other therapeutic molecules across the blood-brain barrier.
