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Cyclo(RADfK)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Cyclo(RADfK) is a selective α(v)β(3) integrin ligand. It has been used for research, therapy, and diagnosis of neoangiogenesis. It is also used as a negative control for the cyclo (-RGDfK-), the RGD peptide, which are modulators of cell adhesion and are recognized by several members of the integrin family. It has low affinity binding to integrin peptides.

Category

Peptide Inhibitors

Catalog number

BAT-010466

CAS number

756500-23-9

Molecular Formula

C28H43N9O7

Molecular Weight

617.70

Specification

IUPAC Name

2-[(2S,5R,8S,11S,14S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-14-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid

Synonyms

c(RADfK); cyclo[L-alanyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl]

Appearance

White to off-white Solid

Purity

≥95%

Density

1.45±0.1 g/cm3 (Predicted)

Sequence

Cyclo (Ala-Asp-D-Phe-Lys-Arg)

Storage

Store at -20°C

Solubility

Soluble in DMSO

Application

Cyclo(RADfK) has been used for research, therapy, and diagnosis of neoangiogenesis. It is also used as a negative control for the cyclo (-RGDfK-), the RGD peptide.

InChI

InChI=1S/C28H43N9O7/c1-16-23(40)36-21(15-22(38)39)27(44)37-20(14-17-8-3-2-4-9-17)26(43)35-18(10-5-6-12-29)25(42)34-19(24(41)33-16)11-7-13-32-28(30)31/h2-4,8-9,16,18-21H,5-7,10-15,29H2,1H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)(H,37,44)(H,38,39)(H4,30,31,32)/t16-,18-,19-,20+,21-/m0/s1

InChI Key

SMFHXHGBDFBWOX-BWUHRYBWSA-N

Canonical SMILES

CC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O