(Cys0)-Amyloid β-Protein (1-40)
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(Cys0)-Amyloid β-Protein (1-40)

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(Cys0)-Amyloid β-Protein (1-40) can be easily and selectively modified, labelled, and coupled to vectors, e.g. by maleimide chemistry, without affecting the sequence involved in fiber formation. The free mercapto moiety of the peptide is attached to the gold surface.

Category
Functional Peptides
Catalog number
BAT-014473
CAS number
208266-35-7
Molecular Formula
C197H300N54O59S2
Molecular Weight
4433.01
IUPAC Name
(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoic acid
Synonyms
H-Cys-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-cysteinyl-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine; Cys-Aβ (1-40)
Appearance
White Powder
Purity
≥90%
Sequence
CDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Storage
Store at -20°C
Solubility
Soluble in Acetonitrile, Water
InChI
InChI=1S/C197H300N54O59S2/c1-25-103(19)160(191(304)214-87-145(260)221-125(67-95(3)4)177(290)231-124(62-66-312-24)174(287)245-154(97(7)8)189(302)212-83-142(257)209-84-147(262)244-156(99(11)12)194(307)249-159(102(17)18)196(309)310)251-195(308)161(104(20)26-2)250-164(277)105(21)218-143(258)85-210-166(279)117(47-36-38-63-198)226-184(297)134(76-141(202)256)238-188(301)139(90-253)223-146(261)88-213-190(303)155(98(9)10)246-187(300)137(79-153(273)274)239-172(285)122(56-60-149(265)266)225-162(275)106(22)219-175(288)128(69-108-41-30-27-31-42-108)235-180(293)130(71-110-45-34-29-35-46-110)241-192(305)158(101(15)16)248-186(299)126(68-96(5)6)233-168(281)118(48-37-39-64-199)227-170(283)120(54-58-140(201)255)229-181(294)131(73-112-80-205-92-215-112)237-183(296)133(75-114-82-207-94-217-114)242-193(306)157(100(13)14)247-173(286)123(57-61-150(267)268)230-178(291)127(72-111-50-52-115(254)53-51-111)222-144(259)86-211-167(280)138(89-252)243-185(298)136(78-152(271)272)240-182(295)132(74-113-81-206-93-216-113)236-169(282)119(49-40-65-208-197(203)204)228-179(292)129(70-109-43-32-28-33-44-109)234-171(284)121(55-59-148(263)264)224-163(276)107(23)220-176(289)135(77-151(269)270)232-165(278)116(200)91-311/h27-35,41-46,50-53,80-82,92-107,116-139,154-161,252-254,311H,25-26,36-40,47-49,54-79,83-91,198-200H2,1-24H3,(H2,201,255)(H2,202,256)(H,205,215)(H,206,216)(H,207,217)(H,209,257)(H,210,279)(H,211,280)(H,212,302)(H,213,303)(H,214,304)(H,218,258)(H,219,288)(H,220,289)(H,221,260)(H,222,259)(H,223,261)(H,224,276)(H,225,275)(H,226,297)(H,227,283)(H,228,292)(H,229,294)(H,230,291)(H,231,290)(H,232,278)(H,233,281)(H,234,284)(H,235,293)(H,236,282)(H,237,296)(H,238,301)(H,239,285)(H,240,295)(H,241,305)(H,242,306)(H,243,298)(H,244,262)(H,245,287)(H,246,300)(H,247,286)(H,248,299)(H,249,307)(H,250,277)(H,251,308)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,309,310)(H4,203,204,208)/t103-,104-,105-,106-,107-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,154-,155-,156-,157-,158-,159-,160-,161-/m0/s1
InChI Key
IKZJNEBQGQZMNN-HQPIFIABSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)N)NC(=O)C(CC3=CN=CN3)NC(=O)C(CC4=CN=CN4)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC6=CN=CN6)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CS)N
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