1.Picky eating in preschool children: Associations with dietary fibre intakes and stool hardness.
Taylor CM1, Northstone K2, Wernimont SM3, Emmett PM4. Appetite. 2016 May 1;100:263-71. doi: 10.1016/j.appet.2016.02.021. Epub 2016 Feb 12.
It has been suggested that constipation may be associated with picky eating. Constipation is a common condition in childhood and a low intake of dietary fibre may be a risk factor. Differences in fibre intake between picky and non-picky children and its relation to stool consistency is currently not well-understood. Children enrolled in the Avon Longitudinal Study of Parents and Children identified as picky eaters (PE) were compared with non-picky eaters (NPE): (1) to determine dietary fibre intake at 38 months; (2) to investigate whether any difference in dietary fibre intake was predictive of usual stool hardness at 42 months. PE was identified from questionnaires at 24 and 38 months. Usual stool hardness was identified from a questionnaire at 42 months. Dietary intake was assessed at 38 months with a food frequency questionnaire. Dietary fibre intake was lower in PE than NPE (mean difference -1.4 (95% CI -1.6, -1.2) g/day, p < 0.001).
2.Supplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival.
Henry L1,2, Fransolet M3, Labied S4,5, Blacher S6, Masereel MC7,8, Foidart JM9, Noel A10, Nisolle M11,12, Munaut C13. J Ovarian Res. 2016 Feb 12;9(1):4. doi: 10.1186/s13048-016-0216-0.
BACKGROUND: Ovarian tissue preservation is proposed to patients at risk of premature ovarian failure, but this procedure still needs to be optimized. To limit injury during ovarian tissue cryopreservation, anti-apoptotic drugs were added to the transport and freezing media of ovarian cortex tissue.
3.Ethnic sensitivity assessment of fluticasone furoate/vilanterol in East Asian asthma patients from randomized double-blind multicentre Phase IIb/III trials.
Gross AS1, Goldfrad C2, Hozawa S3, James MH4, Clifton CS5, Sugiyama Y6, Jacques L7. BMC Pulm Med. 2015 Dec 24;15(1):165. doi: 10.1186/s12890-015-0159-z.
BACKGROUND: Fluticasone furoate (FF)/vilanterol (VI) is a once daily (OD) inhaled corticosteroid/long-acting β2-agonist combination asthma therapy approved in Japan and the EU. FF/VI efficacy and safety data from asthma studies including patients in East Asia were evaluated to assess ethnic sensitivity.
4.Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
Happold C1, Gorlia T1, Chinot O1, Gilbert MR1, Nabors LB1, Wick W1, Pugh SL1, Hegi M1, Cloughesy T1, Roth P1, Reardon DA1, Perry JR1, Mehta MP1, Stupp R1, Weller M2. J Clin Oncol. 2016 Mar 1;34(7):731-9. doi: 10.1200/JCO.2015.63.6563. Epub 2016 Jan 19.
PURPOSE: Symptomatic epilepsy is a common complication of glioblastoma and requires pharmacotherapy. Several uncontrolled retrospective case series and a post hoc analysis of the registration trial for temozolomide indicated an association between valproic acid (VPA) use and improved survival outcomes in patients with newly diagnosed glioblastoma.
