D-Phenylglycine ethyl ester hydrochloride (BAT-007248)
* For research use only

Category
D-Amino Acids
Catalog number
BAT-007248
CAS number
17609-48-2
Molecular Formula
C10H13NO2·HCl
Molecular Weight
215.68
D-Phenylglycine ethyl ester hydrochloride
Synonyms
D-Phg-OEt HCl; (R)-(-)-2-Aminophenylacetic acid ethyl ester hydrochloride; D Phg OEt HCl
Appearance
White powder
Purity
≥ 97% (HPLC)
Density
1.098 g/cm3
Melting Point
179-183 °C
Boiling Point
292.8°C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C10H13NO2.ClH/c1-2-13-10(12)9(11)8-6-4-3-5-7-8;/h3-7,9H,2,11H2,1H3;1H/t9-;/m1./s1
InChI Key
FNNXQLSKQSVNLL-SBSPUUFOSA-N
Canonical SMILES
CCOC(=O)C(C1=CC=CC=C1)N.Cl
1.Endoplasmic reticulum targeting tumour selective photocytotoxic oxovanadium(IV) complexes having vitamin-B6 and acridinyl moieties.
Banerjee S1, Dixit A2, Karande AA2, Chakravarty AR1. Dalton Trans. 2016 Jan 14;45(2):783-96. doi: 10.1039/c5dt03412d.
Oxovanadium(iv) complexes of vitamin-B6 Schiff base, viz., [VO(HL(1)/L(2)/L(3))(B)]Cl (), where B is 2,2'-bipyridine (bpy in and ), 11-(9-acridinyl)dipyrido[3,2-a:2',3'-c]phenazine (acdppz in and ), H2L(1)·HCl is 3-hydroxy-5-(hydroxymethyl)-4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridin-1-ium chloride (in and ), HL(2) is 2-(((2-(1H-imidazol-4-yl)ethyl)imino)methyl)phenol (in ) and HL(3) is 4-(((2-(1H-imidazol-4-yl)ethyl)imino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol (in ) were synthesized, characterized and their cellular uptake, photo-activated cytotoxicity and intracellular localization were studied. Complexes , as the perchlorate salt of , and , as the hexafluorophosphate salt of , were structurally characterized. Vitamin-B6 transporting membrane carrier (VTC) mediated entry into tumour cells in preference to the normal ones seems to be responsible for the higher cellular uptake of the complexes into HeLa and MCF-7 cells over MCF-10A cells.
2.Formulation and Evaluation of Controlled Release Floating Microballoons of Stavudine.
Vidyadhara S1, Sasidhar RL1, Balakrishna T1, Balaji B1, Amrutha R1. Sci Pharm. 2015 Jun 9;83(4):671-82. doi: 10.3797/scipharm.1501-07. eCollection 2015.
The aim of this study was to formulate and evaluate stavudine floating microballoons for controlled drug release. Initially, the drug-loaded low-density granular pellets were prepared with hydroxypropyl methylcellulose E5 grade and by using isopropyl alcohol as a granulating fluid. Further, the low-density granular pellets were subjected to microencapsulation by an emulsion evaporation technique using ethyl cellulose 7 cps and Eudragit S 100 as coating polymers and 1% w/v polyethylene glycol 400 as aqueous phase. The prepared microballoons were characterized for their particle size analysis, angle of repose, and compressibility index. The in vitro release studies were performed in 0.1 N HCl as medium. The prepared microballoons were free-flowing and spherical in shape. From all the formulations, F5E and F5F can be considered as promising controlled release floating microballoons of stavudine providing first-order release over a period of 12 hours, with a minimum floating lag time of 1 minute.
3.Cytotoxic Effect and Constituent Profile of Alkaloid Fractions from Ethanolic Extract of Ficus septica Burm. f. Leaves on T47D Breast Cancer Cells.
Nugroho AE1, Akbar FF, Wiyani A, Sudarsono. Asian Pac J Cancer Prev. 2015;16(16):7337-42.
The study aimed to investigate the profile of alkaloids in two ethyl acetate soluble fractions, namely fractions A and B from an ethanolic extract of Ficus septica leaves and cytotoxic effect on T47D breast cancer cells. Preparation of both fractions involved maceration of leaves with 70% (v/v) ethanol, filtration with Al2O3, precipitation with 0.1 N HCl, Mayer reagent, and 0.1 N NaOH, and also partition with ethyl acetate. Qualitative thin layer chromatography (TLC) was conducted to determine the profile of alkaloids in the two fractions, using alkaloid specific reagents such as Dragendorff, sodium nitrite, and Van Urk-Salkowski. Cytotoxic effects of both fractions on T47D cells were evaluated using MTT assay with a concentration series of 1.56; 3.12; 6.25; 12.5; 25 and 50 μg/mL. The TLC test showed that fractions A and B contained alkaloids with Rx values of 0.74 and 0.80 for fraction A and 0.74, 0.84, 0.92 for fraction B with regard to yohimbine using the mobile phase of n-buthanol:glacial acetic acid:distilled water (3:1:1 v/v/v).
4.Possibilities and limits of pyrolysis for recycling plastic rich waste streams rejected from phones recycling plants.
Caballero BM1, de Marco I2, Adrados A2, López-Urionabarrenechea A2, Solar J2, Gastelu N2. Waste Manag. 2016 Jan 9. pii: S0956-053X(16)30003-4. doi: 10.1016/j.wasman.2016.01.002. [Epub ahead of print]
The possibilities and limits of pyrolysis as a means of recycling plastic rich fractions derived from discarded phones have been studied. Two plastic rich samples (⩾80wt% plastics) derived from landline and mobile phones provided by a Spanish recycling company, have been pyrolysed under N2 in a 3.5dm3 reactor at 500°C for 30min. The landline and mobile phones yielded 58 and 54.5wt% liquids, 16.7 and 12.6wt% gases and 28.3 and 32.4wt% solids respectively. The liquids were a complex mixture of organic products containing valuable chemicals (toluene, styrene, ethyl-benzene, etc.) and with high HHVs (34-38MJkg-1). The solids were composed of metals (mainly Cu, Zn, and Al) and char (≈50wt%). The gases consisted mainly of hydrocarbons and some CO, CO2 and H2. The halogens (Cl, Br) of the original samples were mainly distributed between the gases and solids. The metals and char can be easily separated and the formers may be recycled, but the uses of the char will be restricted due to its Cl/Br content.
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