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D15

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

D15 is an endocytosis inhibitor, blocking the interaction of dynamin with amphiphysin 1 and 2. It impairs AMPA receptor cycling and blocks DHPG-induced long term depression (LTD).

Category
Peptide Inhibitors
Catalog number
BAT-010328
CAS number
251939-41-0
Molecular Formula
C69H111N23O19
Molecular Weight
1566.78
D15
IUPAC Name
2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-5-oxo-2-[[(2S)-1-[(2S)-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetic acid
Synonyms
D15; D 15; D-15
Purity
>98%
Density
1.6±0.1 g/cm3
Sequence
PPPQVPSRPNRAPPG
Storage
Store at -20°C
InChI
InChI=1S/C69H111N23O19/c1-36(2)53(86-55(99)39(22-23-50(70)94)82-59(103)46-18-9-29-89(46)66(110)49-21-12-32-92(49)63(107)40-14-5-24-76-40)67(111)90-30-10-19-47(90)61(105)85-43(35-93)57(101)83-41(15-6-26-78-69(74)75)64(108)87-27-8-17-45(87)60(104)84-42(33-51(71)95)56(100)81-38(13-4-25-77-68(72)73)54(98)80-37(3)62(106)91-31-11-20-48(91)65(109)88-28-7-16-44(88)58(102)79-34-52(96)97/h36-49,53,76,93H,4-35H2,1-3H3,(H2,70,94)(H2,71,95)(H,79,102)(H,80,98)(H,81,100)(H,82,103)(H,83,101)(H,84,104)(H,85,105)(H,86,99)(H,96,97)(H4,72,73,77)(H4,74,75,78)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,53-/m0/s1
InChI Key
CMEJFHBXHREXBP-AVAZHIDJSA-N
Canonical SMILES
CC(C)C(C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)N2CCCC2C(=O)NC(CC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N3CCCC3C(=O)N4CCCC4C(=O)NCC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C5CCCN5C(=O)C6CCCN6C(=O)C7CCCN7
1. Lanthony D15 for Occupational Testing: Short-term Repeatability
Genna Lo, Jason S Ng Optom Vis Sci. 2023 Feb 1;100(2):158-163. doi: 10.1097/OPX.0000000000001991. Epub 2023 Jan 18.
Significance: The Lanthony D15 has been reported to have poorer repeatability than the Farnsworth D15. This study found that two trials of the test provide high short-term repeatability and can be administered this way for occupational testing. Purpose: This study aimed to determine the short-term repeatability of the Lanthony D15 in patients with color vision deficiency. Repeated trials were used to examine if learning effects occur and to determine how many trials would be necessary to ensure the highest short-term repeatability for occupational testing. Methods: Twenty male subjects (mean [standard deviation] age, 27.2 [4.3] years) with congenital color vision deficiency, ranging from mild to severe, participated in this single-visit study. Visual acuity, color vision book screening, Farnsworth D15, and anomaloscope testing were performed for classification purposes. Ten trials of the Lanthony D15 were performed. Color confusion index scores from each trial were determined, and a repeated-measures analysis of variance was used to compare the scores across trials. Orthogonal polynomial analysis was performed to detect any trends across trials through the third order. The intraclass correlation coefficient was calculated. Results: No differences in color confusion index (mean [standard error of the mean], 3.57 [0.04]) were found across the 10 trials ( P = .18). Legendre polynomials showed no statistical significance (all P > .39). The intraclass correlation coefficient was 0.81 (95% confidence interval, 0.70 to 0.90). Based on the method of Shrout and Fleiss, intraclass correlation coefficients of 0.7, 0.8, and 0.9 could be achieved with an average of one, two, and four trials of the test, respectively. However, empirically, 0.9 was not achievable. Conclusions: The Lanthony D15 test has fairly high short-term repeatability. Thus, although more trials would likely improve clinical certainty, the mean result of two trials appears sufficient for occupational testing.
2. Predicting the Farnsworth-Munsell D15 and Holmes-Wright-A lantern outcomes with computer-based color vision tests
Ali Almustanyir, Jeffery Hovis, Mackenzie G Glaholt J Opt Soc Am A Opt Image Sci Vis. 2020 Apr 1;37(4):A1-A10. doi: 10.1364/JOSAA.381305.
This study determined the AC1 agreement values between computer-based color vision tests and the Farnworth-Munsell D-15 (F-D15) and the Holmes-Wright Type A lantern (HWA). The computer-based tests were the United States Air Force Cone Contrast Test (OCCT), Cambridge Color Test, Innova Rabin Cone Contrast, Konan-Waggoner D15 (KWC-D15), and Color Assessment and Diagnosis (CAD). Sixty-eight color-vision-defective persons participated. The KWC-D15 had the highest AC1 with the F-D15 (${\rm AC1} = {0.88}$AC1=0.88). Both the CAD and OCCT had the highest values with the HWA (${\rm AC1} \gt {0.96}$AC1>0.96). The KWC-D15 would be the best substitute for the F-D15. Either the CAD or OCCT would be appropriate substitutes for the HWA.
3. Evaluation of the Waggoner computerized D15 color vision test using an iPad device
Ali Almustanyir, Reema Alduhayan, Mosaad Alhassan, Kholoud Bokhary, Balsam Alabdulkader J Opt Soc Am A Opt Image Sci Vis. 2021 Nov 1;38(11):1647-1655. doi: 10.1364/JOSAA.431987.
The W-D15 test, a computerized variant of the F-D15 test, is used to determine whether an individual with a color vision defect can safely perform color-related tasks. This study evaluated the performance of the W-D15 test using an iPad. Fifty-nine color normal and 61 color vision defect subjects participated. Participants were screened based on the Ishihara, City University Test, and Waggoner PIP24 tests. Different failure criteria of the D15 tests were considered. The pass/failure agreement between the two tests was relatively appropriate, with a κ-coefficient ≥0.8, for all failure criteria. The W-D15 could be an appropriate substitute for F-D15 using an iPad.
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