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Osaka mutation is the first deletion type mutation found in APP and Aβ. Aβ E22delta mutant is more resistant to degradation of two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme. The synthetic mutant Aβ has unusual aggregation properties, with enhanced oligomerization but no fibrillization. It inhibits long-term hippocampal enhancement more effectively than wild-type Aβ.
