DL-m-Tyrosine
Need Assistance?
  • US & Canada:
    +
  • UK: +

DL-m-Tyrosine

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category
DL-Amino Acids
Catalog number
BAT-004810
CAS number
775-06-4
Molecular Formula
C9H11NO3
Molecular Weight
181.2
DL-m-Tyrosine
IUPAC Name
2-amino-3-(3-hydroxyphenyl)propanoic acid
Synonyms
2-amino-3-(3-hydroxyphenyl)propanoic acid; 3-(3-Hydroxyphenyl)-DL-alanine
Appearance
Off-white to grey crystalline powder
Density
1.2375 g/cm3(rough estimate)
Melting Point
268-288 °C
Boiling Point
314.29°C (rough estimate)
Storage
Store at 2-8°C
InChI
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-2-1-3-7(11)4-6/h1-4,8,11H,5,10H2,(H,12,13)
InChI Key
JZKXXXDKRQWDET-UHFFFAOYSA-N
Canonical SMILES
C1=CC(=CC(=C1)O)CC(C(=O)O)N
3. Evaluation of fluorinated m-tyrosine analogs as PET imaging agents of dopamine nerve terminals: comparison with 6-fluoroDOPA
O T DeJesus, C J Endres, S E Shelton, R J Nickles, J E Holden J Nucl Med. 1997 Apr;38(4):630-6.
Fluorinated m-tyrosine analogs were evaluated as PET imaging agents and compared with 6-fluoroDOPA in the visualization of dopamine nerve terminals. Methods: The three m-tyrosine analogs, 6-[18F]fluoro-L-m-tyrosine (6-FMT), 2-[18F]fluoro-L-m-tyrosine (2-FMT) and 6-[18F]fluoro-fluoromethylene-DL-m-tyrosine (6-F-FMMT), were prepared via electrophilic radiofluorination using [18F]acetylhypofluorite. These three analogs, as well as 6-[18F]fluoro-L-DOPA (6-FD), were injected into sets of rhesus monkeys, and serial PET images were acquired. Plasma samples were collected at different times after tracer administration, and metabolite analyses were done using high-performance liquid chromatography (HPLC). Results: Visual inspection of the PET images obtained using these four tracers showed that the best image contrast was obtained with 6-FMT. Patlak analysis with a reference tissue input function yielded a mean uptake rate constant for 6-FMT of 0.019 min-1, a value twice those for the other tracers including 6-FD. Conclusion: These results demonstrate the superiority of 6-[18F]FMT in visualizing dopamine terminals in the rhesus monkey brain and suggest that 6-[18F]FMT is the tracer of choice in the assessment of dopamine metabolism in the living human brain.
Online Inquiry
Verification code
Inquiry Basket