Need Assistance?

  • US & Canada:
  • UK: +
* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

DSPE-mPEG is a phospholipid containing a polyether unit. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers. It is used to study the stability, biodistribution and toxicity of lung-specific liposome anti-tuberculosis drugs.

Peptide Synthesis Reagents
Catalog number
CAS number
Molecular Formula
Molecular Weight
Size Price Stock Quantity
1 g $439 In stock
sodium;[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate
Poly(oxy-1,2-ethanediyl), α-[6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-; 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)]; N-(Carbonyl-methoxypolyethylenglycol)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine, Carbonyl-methoxypolyethylenglycol labeled; N-(Carbamoyl-methoxy peg)-1,2-distearoyl-cephalin; Poly(oxy-1,2-ethanediyl), alpha-((9R)-6-hydroxy-6-oxido-1,12-dioxo-9-((1-oxooctadecyl)oxy)-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl)-omega-methoxy-; α-[6-Hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-Poly(oxy-1,2-ethanediyl)
White to Off-white Solid
>99% by HPLC
Melting Point
53-54 °C
Boiling Point
-20 °C
Soluble in Chloroform (Sparingly), Methanol (Sparingly).
InChI Key
Canonical SMILES
1. EphA2 Targeted Doxorubicin-Nanoliposomes for Osteosarcoma Treatment
Kamran Nazmi,Tymour Forouzanfar,Behrouz Zandieh-Doulabi,Fateme Haghiralsadat,Samira Naderinezhad,Jantine Posthuma De Boer,Ghasem Amoabediny,Marco N Helder Pharm Res . 2017 Dec;34(12):2891-2900. doi: 10.1007/s11095-017-2272-6.
Purpose:To employ Doxorubicin-loaded liposomes, modified with YSA-peptide to target EphA2, to reduce adverse effects against primary bone cells and maximize toxicity against Saos-2 osteosarcoma cells.Methods:PEGylated liposomes were prepared by thin film method using Dipalmitoylphosphatidylcholine (DPPC), cholesterol and distearylphosphatidylethanolamine-polyethyleneglycol conjugate (DSPE-mPEG) in 67.9:29.1:3 M ratios, and loaded with DOX (L-DOX) by pH-gradient method. Targeted liposomes (YSA-L-DOX), were prepared by conjugating YSA-peptide to DSPE-mPEG. Liposomes were physicochemically characterized and tested in cellular toxicity assays.Results:YSA conjugation efficiency was >98%. Size and polydispersity index of both L-DOX and YSA-L-DOX were around 88 nm and 0.188, respectively. Both had similar zeta potential, and 85% DOX loading efficiencies. DOX release kinetics followed the Korsmeyer-Peppa model, and showed comparable release for both formulations from 1-8 h, and a plateau of 29% after 48 h. Both formulations could be stably stored for ≥6 months at 4°C in the dark. Toxicity assays showed a significant 1.91-fold higher cytotoxicity compared to free DOX in the Saos-2 cells, and 2-fold lesser toxicity in primary bone cells compared to the Saos-2 cells. Cellular uptake studies showed higher and more nuclear uptake in YSA-L-DOX compared to L-DOX treated cells.Conclusions:YSA-L-DOX vesicles might be effective for targeted treatment of osteosarcoma.
2. Synthesis of boron carbonitride nanosheets using for delivering paclitaxel and their antitumor activity
Huan Yang,Lijie Luo,Jiaxin Li,Shuidan Gu,Jianbao Li,Yongjun Chen,Changjiu Li,Xi Xie,Lin Jin,Juanxiu Xiao Colloids Surf B Biointerfaces . 2021 Feb;198:111479. doi: 10.1016/j.colsurfb.2020.111479.
As a structural analog of graphene and boron nitride, hexagonal boron carbonitride nanosheets (BCNNSs) are supposed to be a potential drug deliverer. In the present work, an improved solid-state reaction method combined with ultrasonic exfoliating was reported for preparing BCNNSs. Vapor-solid (VS) mechanism was proposed to be responsible for the formation of BCNNSs. The BCNNSs were further modified by DSPE-mPEG-5000 to improve their dispersion in aqueous solution. It was found that the BCNNSs-PEG nanocomplex could be efficiently taken in by MDA-MB-231 breast cancer cells evidenced by inverted fluorescence microscopy. The PEGylated BCNNSs showed an outstanding ability to load paclitaxel through π-π interaction and hydrophobic interaction, and BCNNSs-PEG-loaded paclitaxel presented higher cytotoxicity in comparison with free paclitaxel. BCNNSs may become a promising candidate for delivering paclitaxel and other hydrophobic drugs.
3. [Co-delivery of Pirarubicin and Vinorelbine by Micelles for the Treatment of Breast Cancer]
Dan Chen,Tao Gong,Ting Zhao,Hong-Li Zhou,Chen-Qi Guo,Rong-Ping Zhang,Jia Li Sichuan Da Xue Xue Bao Yi Xue Ban . 2021 Jul;52(4):612-618. doi: 10.12182/20210760105.
Objective:To develop a pirarubicin (THP) and vinorelbine (VRL) codelivery nano-micellar system (T+V-CS micelles) of pirarubicin (THP) and vinorelbine (VRL) by using chondroitin sulfate-cholesterol polymers (CS-Chol) and DSPE-mPEG2000and to evaluate the therapeutic efficacy of the codelivery nano-micelles in breast cancer treatment.Methods:T+V-CS micelles were prepared by ultrasonic-dialysis method, and the physicochemical characterization were evaluated using multiple technological means. The anti-tumor efficacy of T+V-CS micellesin vitrowas evaluated by MTT assay and cell cycle arrest analysis. Evaluation of the therapeutic effect of T+V-CS micellesin vivowas carried out on xenograft 4T1 murine breast cancer bearing BALB/c mice model.Results:T+V-CS micelles displayed a nearly spherical shape when observed through transmission electron microscope. The particle size and polydispersity indexes (PDI) of T+V-CS micelles was (155.5±4.5) nm and 0.170±0.003 respectively, while the Zeta potential was (-23.0±0.9) mV. Meanwhile, T+V-CS micelles demonstrated high encapsulation efficiency of (81.87±2.56)% for THP and (87.54±2.82)% for VRL and a high overall drug loading efficiency of (10.20±1.20)%.In vitroandin vivostudies of the therapeutic efficacy of breast cancer showed that T+V-CS micelles had synergistic anti-tumor effect and induced increased G2/M cell cycle arrest in 4T1 cells, which could significantly inhibit tumor growth and prolong survival compared with the therapeutic efficacy of micelles loaded with a single kind of drug or free drug solutions.Conclusion:The study showed that T+V-CS micelles had excellent anti-tumor effect, offering a reference to the clinical treatment of breast cancer.
4. Post-insertion parameters of PEG-derivatives in phosphocholine-liposomes
Donatella Paolino,Donato Cosco,Christian Celia,Rosario Mare,Massimo Fresta,Roberto Molinaro Int J Pharm . 2018 Dec 1;552(1-2):414-421. doi: 10.1016/j.ijpharm.2018.10.028.
The insertion of specific derivatives into pre-formed colloidal systems has been shown to be a useful method for modifying their pharmacokinetic characteristics and biodistribution profiles. In this experimental work the effect of the post-insertion of different PEG-derivatives into pre-formed 100-nm liposomes made up of various lipid mixtures (DMPC, DPPC, DOPC, DSPC and cholesterol at different molar ratios) was investigated. The vesicles were incubated with increasing amounts of DSPE-mPEG2000as sterically stabilized micelles (5, 10 and 15% w/w with respect to the liposomal lipid mixture) in order to favour the insertion of the PEG-lipid into the liposomal bilayer. The colloidal formulations were characterized by photo-correlation spectroscopy; the DSPE-mPEG2000integrated into the pre-formed liposomes was demonstrated by means of field flow fractionation while the amount of post-inserted compound was quantified using a suitable spectrophotometric assay (I2assay). Similar investigations have been performed using PEG-derivatives characterized by a different molecular weight. The physico-chemical properties of the various liposomal formulations were influenced by the post-insertion of PEG-derivatives. The lipid mixture made up of saturated phospholipids and cholesterol proved to be the best, post-insertion (P.I.E.). The post-insertion technique may be a suitable approach to be used in personalized (nano)medicine.

Online Inquiry

Verification code
Inquiry Basket