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FGL peptide

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

FGL, a NCAM (neural cell adhesion molecule) mimetic peptide, binds to the Fibroblast Growth Factor Receptor 1 (FGFR-1) and has been shown to improve normal memory functioning and mitigate certain pathological cognitive impairments. While FGL does not affect basal synaptic transmission, it facilitates both the induction and maintenance of long-term potentiation (LTP). Additionally, FGL influences heterosynaptic plasticity at adjacent lateral perforant path synapses.

Category

Peptide Inhibitors

Catalog number

BAT-016513

CAS number

499993-62-3

Molecular Formula

C71H116N20O25

Molecular Weight

1649.80

Specification

IUPAC Name

(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-5-amino-1-[[2-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(1S)-1-carboxyethyl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-1,5-dioxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

Synonyms

H-Glu-Val-Tyr-Val-Val-Ala-Glu-Asn-Gln-Gln-Gly-Lys-Ser-Lys-Ala-OH; L-Alanine, L-α-glutamyl-L-valyl-L-tyrosyl-L-valyl-L-valyl-L-alanyl-L-α-glutamyl-L-asparaginyl-L-glutaminyl-L-glutaminylglycyl-L-lysyl-L-seryl-L-lysyl-; L-α-Glutamyl-L-valyl-L-tyrosyl-L-valyl-L-valyl-L-alanyl-L-α-glutamyl-L-asparaginyl-L-glutaminyl-L-glutaminylglycyl-L-lysyl-L-seryl-L-lysyl-L-alanine; FGL; FGL (peptide)

Related CAS

1160048-53-2 (Deleted CAS)

Purity

≥95%

Density

1.325±0.06 g/cm3

Boiling Point

2076.2±65.0 °C at 760 mmHg

Sequence

EVYVVAENQQGKSKA

Storage

Store at 2-8 °C

Solubility

Soluble in Water

InChI

InChI=1S/C71H116N20O25/c1-33(2)55(91-70(114)57(35(5)6)90-66(110)46(29-38-15-17-39(93)18-16-38)87-69(113)56(34(3)4)89-59(103)40(74)19-25-53(98)99)68(112)79-36(7)58(102)82-45(22-26-54(100)101)64(108)86-47(30-51(77)96)65(109)85-44(21-24-50(76)95)63(107)84-43(20-23-49(75)94)60(104)78-31-52(97)81-41(13-9-11-27-72)62(106)88-48(32-92)67(111)83-42(14-10-12-28-73)61(105)80-37(8)71(115)116/h15-18,33-37,40-48,55-57,92-93H,9-14,19-32,72-74H2,1-8H3,(H2,75,94)(H2,76,95)(H2,77,96)(H,78,104)(H,79,112)(H,80,105)(H,81,97)(H,82,102)(H,83,111)(H,84,107)(H,85,109)(H,86,108)(H,87,113)(H,88,106)(H,89,103)(H,90,110)(H,91,114)(H,98,99)(H,100,101)(H,115,116)/t36-,37-,40-,41-,42-,43-,44-,45-,46-,47-,48-,55-,56-,57-/m0/s1

InChI Key

HKTHLRGRESMZQO-RBXNGMIHSA-N

Canonical SMILES

CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)O)NC(=O)C(CCC(=O)O)N