Fmoc-Ala-Ala-Asn(Trt)-PAB
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Fmoc-Ala-Ala-Asn(Trt)-PAB

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Fmoc-Ala-Ala-Asn(Trt)-PAB is a compound used in solid-phase peptide synthesis. It includes a protected tripeptide sequence (two alanines and a trityl-protected asparagine) and a p-aminobenzyl (PAB) linker. The Fmoc and Trt protecting groups safeguard the amino and amide side chains during synthesis, preventing unwanted reactions. The PAB linker can be cleaved under specific conditions, making it useful for designing controlled-release drugs or peptide-based molecules. This combination is often used in the preparation of complex peptides or drug delivery systems.

Category
Peptide Synthesis Reagents
Catalog number
BAT-016511
CAS number
1834515-99-9
Molecular Formula
C51H49N5O7
Molecular Weight
843.96
Fmoc-Ala-Ala-Asn(Trt)-PAB
IUPAC Name
9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1,4-dioxo-4-(tritylamino)butan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamate
Synonyms
Ala-Ala-Asn(Trt)-PAB; (9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1,4-dioxo-4-(tritylamino)butan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-[4-(hydroxymethyl)phenyl]-N5-(triphenylmethyl)-L-aspartamide; Fmoc-Ala-Ala-Asn(Trt)Ph-OH
Purity
≥95%
Density
1.276±0.06 g/cm3
Boiling Point
1144.5±65.0 °C at 760 mmHg
Sequence
Fmoc-Ala-Ala-Asn(Trt)-PAB
Storage
Store at -20 °C
InChI
InChI=1S/C51H49N5O7/c1-33(52-47(59)34(2)53-50(62)63-32-44-42-24-14-12-22-40(42)41-23-13-15-25-43(41)44)48(60)55-45(49(61)54-39-28-26-35(31-57)27-29-39)30-46(58)56-51(36-16-6-3-7-17-36,37-18-8-4-9-19-37)38-20-10-5-11-21-38/h3-29,33-34,44-45,57H,30-32H2,1-2H3,(H,52,59)(H,53,62)(H,54,61)(H,55,60)(H,56,58)/t33-,34-,45-/m0/s1
InChI Key
GGDPZZWZHMXMSD-RHIBOQTESA-N
Canonical SMILES
CC(C(=O)NC(CC(=O)NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)CO)NC(=O)C(C)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57
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