Fmoc-β-alaninol
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Fmoc-β-alaninol

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A building block for the synthesis of oxa-analogues and homologues of naturally occurring polyamines.

Category
Amino Alcohol
Catalog number
BAT-000379
CAS number
157887-82-6
Molecular Formula
C18H19NO3
Molecular Weight
297.4
Fmoc-β-alaninol
IUPAC Name
9H-fluoren-9-ylmethyl N-(3-hydroxypropyl)carbamate
Synonyms
Fmoc-3-aminopropanol; Fmoc-β-Ala-ol; Fmoc-beta-alaninol; 3-(Fmoc-amino)-1-propanol; (9H-Fluoren-9-yl)methyl (3-hydroxypropyl)carbamate; 9H-fluoren-9-ylmethyl N-(3-hydroxypropyl)carbamate
Appearance
White powder
Purity
≥ 99 % (HPLC)
Density
1.212 g/cm3
Boiling Point
518.9 °C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C18H19NO3/c20-11-5-10-19-18(21)22-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17,20H,5,10-12H2,(H,19,21)
InChI Key
GNXZNUJDAMSJFZ-UHFFFAOYSA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCO

Here are key applications of Fmoc-β-alaninol presented with a high degree of perplexity and burstiness:

Peptide Synthesis: Serving as a fundamental component in solid-phase peptide synthesis, Fmoc-β-alaninol plays a pivotal role Its Fmoc-protecting group streamlines its integration into a growing peptide chain while being readily deprotected under mild conditions. This compound facilitates the generation of peptides with tailored sequences and properties catering to both research endeavors and therapeutic applications.

Drug Development: Positioned at the forefront of pharmaceutical exploration, Fmoc-β-alaninol emerges as a critical agent in the creation of peptide-based drug candidates. Its inclusion can bestow distinctive pharmacokinetic and pharmacodynamic attributes upon resultant compounds. Researchers harness the power of this molecule to finely tune factors like oral bioavailability stability and tissue distribution of peptide medications thereby advancing drug development paradigms.

Bioconjugation: Embedded within the realm of bioconjugation strategies, Fmoc-β-alaninol assumes the role of a vital bridge between bioactive molecules and carrier entities. This unique characteristic proves invaluable in the construction of targeted drug delivery systems and diagnostic instruments. By enabling the coupling of therapeutic agents imaging molecules or antibodies to specific targets, Fmoc-β-alaninol elevates the effectiveness of both therapeutic interventions and diagnostic procedures paving the way for enhanced healthcare outcomes.

Structural Biology: In the intricate domain of structural biology, Fmoc-β-alaninol emerges as a versatile tool for probing protein configurations and functionalities. By incorporating this compound into peptide sequences, researchers introduce specific functional groups that aid in the detailed characterization of proteins. This process sheds light on crucial aspects such as protein interactions folding dynamics and molecular behaviors facilitating a deeper understanding of the intricate world of protein structures.

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