Inquiry Basket
Fmoc-Cit-OMe, also known as Fmoc-Citrulline Methyl Ester, is a versatile chemical compound extensively utilized in peptide synthesis and biochemistry research. Here are four key applications of Fmoc-Cit-OMe:
Peptide Synthesis: Acting as a pivotal component in solid-phase peptide synthesis, Fmoc-Cit-OMe serves as a crucial building block. Its Fmoc protective group, easily removable under mildly basic conditions, facilitates the gradual assembly of peptides. Notably, peptides containing citrulline synthesized using this compound offer invaluable insights into enzyme interactions and the creation of therapeutic peptides, unlocking intricate research avenues.
Biomolecular Research: In the realm of biomolecular research, Fmoc-Cit-OMe holds significant utility, especially in the exploration of citrullination, a post-translational modification implicated in various physiological and pathological processes. Researchers leverage this compound to introduce citrulline residues into peptides and proteins, shedding light on the role of citrullinated proteins in autoimmune diseases like rheumatoid arthritis. Vital for synthesizing synthetic targets for antibody detection and enzyme assays, Fmoc-Cit-OMe spearheads cutting-edge research endeavors.
Protein Engineering: Within the domain of protein engineering, Fmoc-Cit-OMe emerges as a pivotal tool for incorporating citrulline residues into proteins, offering researchers a glimpse into the dynamics of protein structure and function. This unique modification can intricately influence protein folding and interactions, providing profound insights into protein regulation and stability. Through this application, scientists can craft novel proteins with customized properties suitable for therapeutic and industrial applications.
Diagnostic Development: Playing a crucial role in the development of diagnostic reagents for detecting citrullinated peptides and proteins, Fmoc-Cit-OMe is essential in identifying biomarkers associated with autoimmune disorders. By utilizing derivatives of Fmoc-Cit-OMe, researchers can design highly specific assays for enhanced disease diagnosis and monitoring, elevating precision and efficacy in diagnostic development pursuits. This application underscores the compound’s indispensable role in advancing diagnostic capabilities within the realm of biochemistry research.
