1.Hydroxymethyl Salicylaldehyde Auxiliary for a Glycine-Dependent Amide-Forming Ligation.
Fouché M1, Masse F1, Roth HJ1. Org Lett. 2015 Oct 16;17(20):4936-9. doi: 10.1021/acs.orglett.5b02350. Epub 2015 Oct 1.
A new amide-forming ligation that requires a glycine or a primary amine at the linkage site is described herein. The distinguishing feature of this ligation is its reliance on an O-hydroxymethyl salicylaldehyde ester at the C-terminus which allows, via an N,O-acetal intermediate, the formation of a native peptide bond.