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Fmoc-Gly-Gly-OH

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category

Others

Catalog number

BAT-004994

CAS number

35665-38-4

Molecular Formula

C19H18N2O5

Molecular Weight

354.36

Specification
Reference Reading

IUPAC Name

2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid

Synonyms

N-Fmoc-L-glycylglycine; 2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)acetamido)acetic acid

Appearance

White powder

Purity

>99.3%

Density

1.338±0.06 g/cm3(Predicted)

Melting Point

176-177 °C

Boiling Point

684.1±45.0 °C(Predicted)

Storage

-20°C

Solubility

10 mm in DMSO

InChI

InChI=1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24)

InChI Key

FBKUOPULLUJMOC-UHFFFAOYSA-N

Canonical SMILES

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCC(=O)NCC(=O)O

1.Hydroxymethyl Salicylaldehyde Auxiliary for a Glycine-Dependent Amide-Forming Ligation.

Fouché M1, Masse F1, Roth HJ1. Org Lett. 2015 Oct 16;17(20):4936-9. doi: 10.1021/acs.orglett.5b02350. Epub 2015 Oct 1.

A new amide-forming ligation that requires a glycine or a primary amine at the linkage site is described herein. The distinguishing feature of this ligation is its reliance on an O-hydroxymethyl salicylaldehyde ester at the C-terminus which allows, via an N,O-acetal intermediate, the formation of a native peptide bond.