Fmoc-iminodiacetic acid
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Fmoc-iminodiacetic acid

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Category
Fmoc-Amino Acids
Catalog number
BAT-007433
CAS number
112918-82-8
Molecular Formula
C19H17NO6
Molecular Weight
355.34
Fmoc-iminodiacetic acid
IUPAC Name
2-[carboxymethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic acid
Synonyms
Fmoc-Ida-OH; Fmoc Ida OH
Appearance
White powder
Purity
≥ 99% (HPLC)
Density
1.41 g/cm3
Melting Point
213-217°C
Boiling Point
618.4°C at 760 mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C19H17NO6/c21-17(22)9-20(10-18(23)24)19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,21,22)(H,23,24)
InChI Key
LNHILYINDTUUMZ-UHFFFAOYSA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N(CC(=O)O)CC(=O)O
1.Comprehensive Mitochondrial Metabolic Shift during the Critical Node of Seed Ageing in Rice.
Yin G1, Whelan J2, Wu S1, Zhou J1, Chen B1,3, Chen X1, Zhang J1, He J1, Xin X1, Lu X1. PLoS One. 2016 Apr 28;11(4):e0148013. doi: 10.1371/journal.pone.0148013.
The critical node (CN) in seed aging in rice (Oryza sativa) is the transformation from Phase I (P-I) to Phase II (P-II) of the reverse S-shaped curve (RS-SC). Although mitochondrial dysfunction plays a key role in seed ageing, the metabolic shift in the CN remains poorly understood. Here, we investigated the mitochondrial regulatory mechanisms during the CN of rice seed ageing. We showed that during the CN of seed ageing, the mitochondrial ultrastructure was impaired, causing oxygen consumption to decrease, along with cytochrome c (cyt c) oxidase and malate dehydrogenase (MDH) activity. In addition, the transcript levels for the alternative pathway of the electron transport chain (ETC) were significantly induced, whereas the transcripts of the cytochrome oxidase (COX) pathway were inhibited. These changes were concomitant with the down-regulation of mitochondrial protein levels related to carbon and nitrogen metabolism, ATP synthase (ATPase) complex, tricarboxylic acid cycle (TCA) cycle, mitochondrial oxidative enzymes, and a variety of other proteins.
2.Sensitivity of HIV rapid tests compared to fourth generation enzyme immunoassays or HIV RNA tests - a systematic review and meta-analysis.
Tan WS1, Chow EP, Fairley CK, Chen MY, Bradshaw CS, Read TR. AIDS. 2016 Apr 27. [Epub ahead of print]
OBJECTIVE: Determine the sensitivity of rapid HIV tests (RT) compared to fourth generation enzyme immunoassays (EIA) or nucleic acid amplification tests (NAAT) in clinical settings.
3.Identification of Factors Affecting the Success of Next-Generation Sequencing Testing in Solid Tumors.
Goswami RS1, Luthra R2, Singh RR1, Patel KP1, Routbort MJ1, Aldape KD3, Yao H4, Dang HD1, Barkoh BA1, Manekia J1, Medeiros LJ1, Roy-Chowdhuri S3, Stewart J3, Broaddus RR3, Chen H3. Am J Clin Pathol. 2016 Feb;145(2):222-237. Epub 2016 Feb 12.
OBJECTIVES: Clinical laboratories are rapidly implementing next-generation sequencing (NGS) tests for mutation analysis, but there are few guidelines regarding sample quality for successful results.
4.Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia.
Yoshida M1,2, He P1, Yun CC1,3. PLoS One. 2016 Apr 28;11(4):e0154527. doi: 10.1371/journal.pone.0154527.
Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA2 attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA2 alone can lead to malignant transformation in the intestinal tract has not been studied. In this study, we expressed human LPA2 in intestinal epithelial cells (IECs) under control of the villin promoter. Less than 4% of F1-generation mice had germline transmission of transgenic (TG) human LPA2; as such only 3 F1 mice out of 72 genotyped had TG expression. These TG mice appeared anemic with hematochezia and died shortly after birth. TG mice were smaller in size compared with the wild type mouse of the same age and sex. Morphological analysis showed that TG LPA2 colon had hyper-proliferation of IECs resulting in increased colonic crypt depth. Surprisingly, TG small intestine had villus blunting and decreased IEC proliferation and dysplasia.
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