Fmoc-L-α-aminobutyric acid
Need Assistance?
  • US & Canada:
    +
  • UK: +

Fmoc-L-α-aminobutyric acid

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category
Fmoc-Amino Acids
Catalog number
BAT-007435
CAS number
135112-27-5
Molecular Formula
C19H19NO4
Molecular Weight
325.36
Fmoc-L-α-aminobutyric acid
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
Synonyms
Fmoc-L-Abu-OH; Fmoc-L-2-aminobutanoic acid; Fmoc L Abu OH
Purity
98+%
Density
1.3±0.1 g/cm3
Melting Point
161-163°C
Boiling Point
550.7±33.0 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C19H19NO4/c1-2-17(18(21)22)20-19(23)24-11-16-14-9-5-3-7-12(14)13-8-4-6-10-15(13)16/h3-10,16-17H,2,11H2,1H3,(H,20,23)(H,21,22)/t17-/m0/s1
InChI Key
XQIRYUNKLVPVRR-KRWDZBQOSA-N
Canonical SMILES
CCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
1.Ultra-trace graphene oxide in a water environment triggers Parkinson's disease-like symptoms and metabolic disturbance in zebrafish larvae.
Ren C1, Hu X2, Li X3, Zhou Q4. Biomaterials. 2016 Mar 31;93:83-94. doi: 10.1016/j.biomaterials.2016.03.036. [Epub ahead of print]
Over the past decade, the safety of nanomaterials has attracted attention due to their rapid development. The relevant health threat of these materials remains largely unknown, particularly at environmentally or biologically relevant ultra-trace concentrations. To address this, we first found that graphene oxide (GO, a carbon nanomaterial that receives extensive attention across various disciplines) at concentrations of 0.01 μg/L-1 μg/L induced Parkinson's disease-like symptoms in zebrafish larvae. In this model, zebrafish showed a loss of more than 90% of dopamine neurons, a 69-522% increase in Lewy bodies (α-synuclein and ubiquitin) and significantly disturbed locomotive activity. Moreover, it was also shown that GO was able to translocate from the water environment to the brain and localize to the nucleus of the diencephalon, thereby inducing structural and morphological damage in the mitochondria. Cell apoptosis and senescence were triggered via oxidative stress, as shown by the upregulation of caspase 8 and β-galactosidase.
2.A Pycnoporus sanguineus laccase for denim bleaching and its comparison with an enzymatic commercial formulation.
Iracheta-Cárdenas MM1, Rocha-Peña MA2, Galán-Wong LJ3, Arévalo-Niño K4, Tovar-Herrera OE5. J Environ Manage. 2016 Apr 13;177:93-100. doi: 10.1016/j.jenvman.2016.04.008. [Epub ahead of print]
A laccase from the basidiomycete Pycnoporus sanguineus strain RVAN5 was evaluated for its ability to decolorize synthetic dyes and denim bleaching. Dye color reduction and denim bleaching were monitored at different dye concentrations and incubation times. Dye decolorization by Pycnoporus sanguineus fungal crude extract (FCE) ranged from 80 to 96% within 2-4 h at 25-65 °C. Comparable results were obtained when violuric acid (VA) was added as mediator to the FCE, however, the number of decolorized dyes increased significantly. Dye decolorization rates with VA varied of initial and final optical density (595 nm) values of 2.5-3.0 and 0.2-0.02, respectively. P. sanguineus FCE had no substantial effect on denim bleaching when used alone, notwithstanding, the mixture of FCE with VA (10 mM) showed significant denim color reduction values and considerably higher than those obtained with a bleaching enzyme from a commercial formulation; CIElab values obtained with FCE/VA mixture were of ΔL = 6.
3.Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors.
Ogawa K1, Ueno T2, Iwasaki T3, Kujiraoka T3, Ishihara M3, Kunimoto S4, Takayama T4, Kanai T4, Hirayama A4, Hattori H3. Atherosclerosis. 2016 Apr 1;249:110-115. doi: 10.1016/j.atherosclerosis.2016.03.041. [Epub ahead of print]
OBJECTIVE: Sortilin is involved multilaterally in the development of atherosclerosis. Here, we examine the release of soluble sortilin (sSortilin) from platelets and assess the association between circulating levels of sSoritlin and atherothrombosis such as coronary artery disease (CAD).
4.The bile acid Deoxycholate Elicits defenses in Arabidopsis and reduces bacterial infection.
Zarattini M1,2, Launay A1,3, Farjad M1, Wénès E1, Taconnat L4, Boutet S1, Bernacchia G2, Fagard M1. Mol Plant Pathol. 2016 Apr 16. doi: 10.1111/mpp.12416. [Epub ahead of print]
Crop yield loss is significantly affected by disease. Considering that the worldwide demand for agricultural products is increasing, there is a need to pursue the development of new methods to protect crops from disease. One mechanism of plant protection is through the activation of its immune system. By exogenous application, "plant activator molecules" with elicitor properties, can be used to activate the plant immune system. These defense-inducing molecules represent a powerful and often environment-friendly toolset to fight pathogens. We show that the secondary bile acid deoxycholic acid (DCA) induces defense in Arabidopsis and reduces the proliferation of two bacterial phytopathogens, Erwinia amylovora and Pseudomonas syringae pv. tomato. We describe the global defense response triggered by this new plant activator in Arabidopsis at the transcriptional level. Several induced genes were selected for further analysis by qRT-PCR: we describe the kinetics of their induction and we show that abiotic stress, such as moderate drought or nitrogen limitation, does not impede DCA induction of defense.
Online Inquiry
Verification code
Inquiry Basket