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Fmoc-L-aspartic acid β-tert-butyl ester α-N-hydroxysuccinimide ester plays a pivotal role in peptide synthesis and bioconjugation. Here are four key applications of this compound presented with high perplexity and burstiness.
Peptide Synthesis: This specialized reagent features prominently in solid-phase peptide synthesis (SPPS), a technique utilized to craft custom peptides of exceptional purity. By safeguarding the N-terminal end and side chain of aspartic acid, it ensures precise deprotection during the elongation process, thereby streamlining the production of intricate peptides tailored for diverse research and pharmaceutical endeavors.
Protein Labeling: With its ester functional group, this compound serves as a potent crosslinker in protein labeling applications. By engaging with amine groups on proteins, it proficiently conjugates fluorophores, biotin, or other labels to proteins, facilitating pivotal techniques like fluorescence microscopy, Western blotting, and flow cytometry, thus broadening the horizons of protein analysis and visualization.
Bioconjugation: Embedded within bioconjugation strategies, Fmoc-L-aspartic acid β-tert-butyl ester α-N-hydroxysuccinimide ester acts as a linchpin in linking peptides with a myriad of biomolecules. Whether conjugated to antibodies, enzymes, or nucleic acids, this compound enhances the functionality and detectability of these bioconjugates, playing an indispensable role in the creation of diagnostic assays and therapeutic agents that push the boundaries of medical innovation.
Drug Delivery Systems: In the domain of drug delivery systems, this compound emerges as a crucial component in facilitating the targeted delivery of therapeutic agents. By enabling the attachment of peptides to drug carriers such as nanoparticles or liposomes, it propels the precise delivery of therapeutic payloads to designated sites, enhancing treatment efficacy while mitigating adverse side effects.
